WormBase Tree Display for Gene: WBGene00000501

WBGene00000501 SMap: S_parent: Sequence: C48D1
  Identity: Version: 1
    Name: CGC_name: cho-1 Person_evidence: WBPerson508
      Sequence_name: C48D1.3
      Molecular_name: C48D1.3
        C48D1.3.1
        CE27109
      Other_name: CELE_C48D1.3 Accession_evidence: NDB BX284604
      Public_name: cho-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cho
    Allele: WBVar00952862
      WBVar00952863
      WBVar00952864
      WBVar00952865
      WBVar00952866
      WBVar02042231
      WBVar00952867
      WBVar00952868
      WBVar02042232
      WBVar00952869
      WBVar02042233
      WBVar02042234
      WBVar00952870
      WBVar00952871
      WBVar00952872
      WBVar01500079
      WBVar00952873
      WBVar00952874
      WBVar00952875
      WBVar00952876
      WBVar00952877
      WBVar00952878
      WBVar00952879
      WBVar00952880
      WBVar00952881
      WBVar00952882
      WBVar00952883
      WBVar00952884
      WBVar00952885
      WBVar00952886
      WBVar02037436
      WBVar00952887
      WBVar00952888
      WBVar00952889
      WBVar00952890
      WBVar00952891
      WBVar00952892
      WBVar00952893
      WBVar00952894
      WBVar01498996
      WBVar00952895
      WBVar00952896
      WBVar00952897
      WBVar00952898
      WBVar00952899
      WBVar00952900
      WBVar00952901
      WBVar01499925
      WBVar02021396
      WBVar01967351
      WBVar01967352
      WBVar00304454
      WBVar00249421
      WBVar01804698
      WBVar01804699
      WBVar01804700
      WBVar01804701
      WBVar01804702
      WBVar01804703
      WBVar01804704
      WBVar01804705
      WBVar01804706
      WBVar01804707
      WBVar01804708
      WBVar01804709
      WBVar00439274
      WBVar00439275
      WBVar00439276
      WBVar00439277
      WBVar02078383
      WBVar00439278
      WBVar00439279
      WBVar00092338
      WBVar00439280
      WBVar01796463
      WBVar01499492
      WBVar01499493
      WBVar01581900
      WBVar01581901
      WBVar01731431
      WBVar01731432
      WBVar00193165
      WBVar00193166
      WBVar01500245
      WBVar00193167
      WBVar00575079
      WBVar00193168
      WBVar00193169
      WBVar00193170
      WBVar00193171
      WBVar00193172
    Strain: WBStrain00004034
      WBStrain00004035
      WBStrain00033386
      WBStrain00033389
      WBStrain00036129
      WBStrain00033405
      WBStrain00033393
      WBStrain00033404
      WBStrain00033403
      WBStrain00033406
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (41)
    Paralog: WBGene00014092 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018716 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: cho-1 encodes a high-affinity choline transporter orthologous to members of the sodium-dependent glucose transporter family; CHO-1 is expressed in cholinergic neurons. Paper_evidence: WBPaper00003947
            WBPaper00019363
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables choline transmembrane transporter activity. Involved in choline transport. Located in axon; neuronal cell body; and synaptic vesicle. Expressed in head mesodermal cell; intestine; nerve ring; and neurons. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 20; distal hereditary motor neuronopathy type 7A; and major depressive disorder. Is an ortholog of human SLC5A7 (solute carrier family 5 member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111201 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14025)
      DOID:1470 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14025)
      DOID:1596 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14025)
      DOID:0110661 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14025)
  Molecular_info: Corresponding_CDS: C48D1.3
    Corresponding_CDS_history: C48D1.3:wp47
    Corresponding_transcript: C48D1.3.1
    Other_sequence (24)
    Associated_feature: WBsf945409 Paper_evidence: WBPaper00044605
      WBsf998358
      WBsf998359
      WBsf998360
      WBsf998361
      WBsf1018504
      WBsf1018505
      WBsf231100
  Experimental_info: RNAi_result: WBRNAi00007265 Inferred_automatically: RNAi_primary
      WBRNAi00029943 Inferred_automatically: RNAi_primary
      WBRNAi00042733 Inferred_automatically: RNAi_primary
      WBRNAi00075846 Inferred_automatically: RNAi_primary
      WBRNAi00012101 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct (22)
    Construct_product (11)
    Microarray_results (18)
    Expression_cluster: WBPaper00032425:up_in_rde-4
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035211:age-1_vs_N2_downregulated
      WBPaper00037950:A-class-motor-neurons_CoreEnriched
      WBPaper00037950:A-class-motor-neurons_embryo_enriched
      WBPaper00037950:A-class-motor-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:all-neurons_larva_SelectivelyEnriched
      WBPaper00037950:AVE-neuron_embryo_enriched
      WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038061:aldicarb_upregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:AIY
      WBPaper00061340:AVL
      WBPaper00061340:Neuroblast_HSN_PHB
      WBPaper00061340:RMD
      WBPaper00061340:SMD
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:xbx-3-DH11.5_20397
      WBPaper00061651:AIA_enriched
      WBPaper00061651:AIN_enriched
      WBPaper00061651:AS_enriched
      WBPaper00061651:DA_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061651:M5_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PVP_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:RIF_enriched
      WBPaper00061651:RIH_enriched
      WBPaper00061651:RIR_enriched
      WBPaper00061651:RIV_enriched
      WBPaper00061651:RMD_DV_enriched
      WBPaper00061651:RMD_LR_enriched
      WBPaper00061651:RMF_enriched
      WBPaper00061651:RMH_enriched
      WBPaper00061651:SAB_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:URA_enriched
      WBPaper00061651:VA_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064789:Day12_vs_Day1_upregulated_neuron
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:6_0
      WBPaper00065841:6_1
      WBPaper00065841:6_2
      WBPaper00065841:6_3
      WBPaper00065841:14_1
      WBPaper00065841:22_0
      WBPaper00065841:28_0
      WBPaper00065841:29_0
      WBPaper00065841:32_0
      WBPaper00065841:46_0
      WBPaper00065841:50_0
      WBPaper00065841:52_0
      WBPaper00065841:55_0
      WBPaper00065841:76_0
      WBPaper00065841:96_0
      WBPaper00065841:103_0
      WBPaper00065841:104_0
      WBPaper00065841:111_0
      WBPaper00065841:117_0
      WBPaper00065841:121_0
      WBPaper00065841:126_0
      WBPaper00065841:128_0
      WBPaper00065841:130_0
      WBPaper00065841:133_0
      WBPaper00065841:134_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_14
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00036286:Pattern_I
      WBPaper00040876:mir-35_downregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
    Interaction (22)
  Map_info: Map: IV Position: 8.47547 Error: 0.003353
    Positive: Positive_clone: C48D1 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4218
    Pseudo_map_position
  Reference (22)
  Remark: Sequence connection from [Okuda T, Katsura I]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene