WormBase Tree Display for GO_term: GO:0035195
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| GO:0035195 | Name | miRNA-mediated post-transcriptional gene silencing | |
|---|---|---|---|
| Definition | A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. | ||
| Synonym (2) | |||
| Status | Valid | ||
| Type | Biological_process | ||
| Child (2) | |||
| Parent | Instance_of | GO:0035194 | |
| Attributes_of (2) | |||
| Version | Gene Ontology releases/2023-11-15 |
