WormBase Tree Display for Expr_pattern: Expr9341
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| Expr9341 | Expression_of | Gene | WBGene00001978 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00001978 | |||
| Expression_data | Life_stage | WBls:0000003 | ||
| Anatomy_term | WBbt:0005460 | Certain | ||
| WBbt:0005792 | Certain | |||
| WBbt:0007846 | Certain | |||
| GO_term | GO:0005737 | |||
| GO:0005913 | ||||
| Subcellular_localization | HMP-1 expression: Before morphogenesis and tissue differentiation, the HMP-1 antiserum stains all blastomeres of embryos. HMP-1 antiserum prominently labels all regions of contact between blastomeres, in addition to showing diffuse cytoplasmic staining. At approximately the time adherens junctions begin to form in the hypodermis, HMP-1 protein accumulates to high levels along the apical margins of all hypodermal cells (all hypodermal staining lies within a 1-um focal plane near the cell surface). During migration of ventral hypodermal cells, HMP-1 antiserum staining is not detected at the leading edges of these cells. HMP-1 becomes localized to the ventral margins of these cells as they contact contralateral cells at the ventral midline. During body elongation, the HMP-1 antiserum stains predominantly the apical margins of all hypodermal, pharyngeal, and intestinal cells, as does the mAbMH27 antiserum. The staining of these two antisera appears to colocalize, strongly suggesting that HMP-1 is a component of the adherens junctions. In later stages, staining appeared most prominent on the margins of the hypodermal cells that abut the two ends of the CFBs. | |||
| Type | Antibody | Polyclonal rabbit antibodies against a HMP-1 fusion protein. | ||
| Picture | WBPicture0000008903 | |||
| WBPicture0000008904 | ||||
| Reference | WBPaper00003046 | |||
| Antibody_info | WBAntibody00000167 |
