WormBase Tree Display for Expr_pattern: Expr2758
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| Expr2758 | Expression_of | Gene | WBGene00006579 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00006579 | |||
| Expression_data | Life_stage | WBls:0000003 | ||
| WBls:0000057 | ||||
| Anatomy_term | WBbt:0005784 | Certain | ||
| GO_term | GO:0005634 | |||
| Subcellular_localization | Examination of TLK-1 immunostaining with respect to the cell cycle revealed that TLK-1 was highly expressed in interphase and prophase nuclei. TLK-1 immunostaining diminished dramatically upon nuclear envelope break-down and did not appear to be above background levels in mitotic cells from metaphase through telophase. However, it is impossible to distinguish whether this is due to diffusion of nuclear TLK-1 or due to degradation of the TLK-1 protein during mitosis. | |||
| Type | Antibody | |||
| Pattern | TLK-1 protein was exclusively found in nuclei from the 2-cell stage until morphogenesis. TLK-1 was also detectable in adult germline nuclei, suggesting that the TLK-1 protein is maternally expressed. | |||
| Picture | WBPicture0000009761 | |||
| Remark | Staining was completely eliminated in tlk-1(RNAi) embryos and entirely competed by preincubation of TLK-1 antisera with MBP-TLK-1. | |||
| Reference | WBPaper00006181 | |||
| Antibody_info | WBAntibody00000692 |
