WormBase Tree Display for Expr_pattern: Expr11648
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| Expr11648 | Expression_of | Gene | WBGene00015334 | ||
|---|---|---|---|---|---|
| WBGene00006319 | |||||
| Reflects_endogenous_expression_of | WBGene00006319 | ||||
| WBGene00015334 | |||||
| Expression_data | Anatomy_term | WBbt:0004292 | Certain | ||
| WBbt:0005813 | Certain | ||||
| WBbt:0005821 | Certain | ||||
| WBbt:0006751 | Partial | ||||
| Remark | Expressed in three neurons in the head. | ||||
| GO_term | GO:0097433 | ||||
| Type | Reporter_gene | ||||
| Pattern | Similar to transgenic animals expressing a Psup-10::gfp translational fusion transgene, Psup-18::gfp transgenic animals displayed GFP fluorescence in body-wall, defecation and vulval muscles. In body-wall muscle cells, the SUP-10::GFP and SUP-18::GFP fusion proteins both localized to cell-surface regions aligned with dense bodies, the functional analogs to vertebrate Z-lines that connect the myofibril lattice to the cell membrane. In addition to muscles, three neurons in the head of Psup-18::gfp transgenic animals also displayed GFP staining. The authors previously reported expression of a Psup-9::gfp reporter in the four SIA interneurons. They stained the Psup-18::gfp transgenic animals with an anti-CEH-17 antibody, which labels the four SIA neurons and the ALA neuron, and found that the neurons expressing the SUP-18::GFP fusion protein were not the SIAs. SUP- 10 and SUP-18 colocalize in subcellular structures, including the dense bodies in the body-wall muscles. Since GFP fusions to SUP-9 and UNC-93 localize similarly, this result suggests that SUP-18 colocalizes with a SUP-9/UNC-93/SUP-10 complex. | ||||
| Picture | WBPicture0000013599 | ||||
| Reference | WBPaper00044940 | ||||
| Transgene | WBTransgene00031574 |
