WormBase Tree Display for Expr_pattern: Expr1084

Expr1084 Expression_of: Gene: WBGene00003002
    Reflects_endogenous_expression_of: WBGene00003002
  Expression_data: Life_stage: WBls:0000002
    Anatomy_term: WBbt:0005734 Certain
      WBbt:0005753 Certain
      WBbt:0008112 Uncertain
        Remark: Occasional expression.
      WBbt:0008117 Uncertain
        Remark: Occasional expression.
      WBbt:0008121 Uncertain
        Remark: Occasional expression.
      WBbt:0008125 Uncertain
        Remark: Occasional expression.
      WBbt:0008129 Uncertain
        Remark: Occasional expression.
      WBbt:0008133 Uncertain
        Remark: Occasional expression.
    GO_term: GO:0005634
  Subcellular_localization: The LIN-13::GFP hybrid proteins localize to the nucleus. In the nucleus, there are also discrete bodies or speckles of fluorescence; other nuclear proteins have been found to localize in such patterns, but in most cases the functional significance of these structures is not clear. Nuclear accumulation observed in other cell types (not characterized in detail, but the expression pattern of LIN-13::GFP seems roughly equivalent to that of lin-13::lacZ).
  Type: Reporter_gene
  Pattern: Significant GFP fluorescence seen in embryos of living animals (not determined the cell types). In living larvae, however, expression is very low, and in particular no expression was detected during the L3 stage. Hermaphrodites fixed and stained with antibodies to GFP showed consistent LIN-13::GFP accumulation in the nuclei of hyp7 and in seam cells throughout development, including the L3 stage. No reliable expression of LIN-13::GFP observed in the VPCs, although occasionally detected GFP in one or two VPCs in fixed and antibody-stained hermaphrodites.
  Picture: WBPicture0000011722
  Remark: Transgenes expressing either of these LIN-13::GFP hybrid proteins fully rescue the Muv and sterility defects of lin-13(n387) and appear to have identical expression patterns.
  Reference: WBPaper00004202
  Transgene: WBTransgene00000049
    WBTransgene00000050