WormBase Tree Display for Disease_model_annotation: WBDOannot00001325
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| WBDOannot00001325 | Disease_term | DOID:14330 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00004039 | |
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Experimental_condition | Inducing_chemical | WBMol:00002747 | |
| Modifier_info | Modifier_molecule | WBMol:00007996 | |
| Modifier_association_type | condition_ameliorated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00064474 | ||
| Disease_model_description | The pesticide Paraquat is an ecological neurotoxin that can worsen and mimic Parkinson's disease onset and progression; worms exposed to PQ develop behavioral and biochemical changes that resemble PD symptoms, such as decreased dopamine resulting in compromised locomotor function. BZ555 worms (specifically express GFP in dopaminergic neurons) incubated with citric acid sourced carbon quantum dots (Cit-CQDs) are protected from paraquat induced neuronal damage. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 10 Oct 2022 00:00:00 |
