WormBase Tree Display for Disease_model_annotation: WBDOannot00001238
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| WBDOannot00001238 | Disease_term | DOID:9351 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00052377 | |
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00062344 | ||
| Disease_model_description | Increased expression of grh-1 positively regulates nematode lifespan and impacts insulin signaling; murine and human orthologs are also indicated to do so based on correlative data from genome-wide association studies. Small-molecule compounds, including the FDA-approved phytochemical papaverine, are identified as human GRHL1 activators, capable of extending nematode lifespan through GRH-1. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 08 Jun 2022 00:00:00 |
