WormBase Tree Display for Disease_model_annotation: WBDOannot00000844
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| WBDOannot00000844 | Disease_term | DOID:10652 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00007866 | |
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Modifier_molecule | WBMol:00007786 | |
| Other_modifier | A-beta(1-38) peptide | ||
| Modifier_association_type | condition_ameliorated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00060860 | ||
| Disease_model_description | GMC101 is a transgenic strain that expresses full length A-beta (1-42) and differs from other models that predominantly express amino-truncated A-beta (3-42); the A-beta (1-42) is expressed in body wall muscle cells, where it oligomerizes, aggregates and results in severe, and fully penetrant, age progressive-paralysis; a naturally occurring variant, A-beta(1-38) peptide when expressed in GMC101 reverses the negative effects of A-beta(1-42). | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 21 Jan 2021 00:00:00 |
