WormBase Tree Display for Disease_model_annotation: WBDOannot00000804
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| WBDOannot00000804 | Disease_term | DOID:10652 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Strain | WBStrain00047971 | |
| Asserted_human_gene | HGNC:6893 | ||
| Association_type | is_model_of | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Experimental_condition | Inducing_chemical | WBMol:00002747 | |
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00060195 | ||
| Disease_model_description | A transgenic C. elegans strain where human TauT4 wild type is expressed and causes neurodegeneration; the induction of mitophagy occurring in response to the mitochondrial toxin paraquat was entirely suppressed by expression of the phospho-mimetic Tau(T231E) and acetylation mimicking Tau(K274Q,K281Q) mutants in transgenic elegans strains, but not in the wild type Tau strain; specific disease-associated Tau mutations act cell autonomously (early in life) to elevate the mitochondrial Unfolded Protein Response (UPR). | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 19 Sep 2020 00:00:00 |
