WormBase Tree Display for DO_term: DOID:0080208

DOID:0080208 Name: metabolic dysfunction-associated steatotic liver disease
  Status: Valid
  Definition: A steatotic liver disease characterized by at least one of five cardiometabolic risk factors (adjusted for age, sex and ethnicity), alcohol consumption below 140g/week (female) or 210g/week (male), and no other discernible cause. The five cardiometabolic risk factors are: (1) Body mass index 25 kg/m2 (adult), 23 kg/m2 (adult Asian), or 85th percentile (pediatric); waist circumference > 94 cm (adult male), 80 cm (adult female), or 95th percentile (pediatric); or ethnicity adjusted equivalents. (2) Fasting serum glucose 5.6 mmol/L, 2-hr post-load glucose levels 7.8 mmol/L, glycated hemoglobin (HbA1c) 5.7% (39 mmol/L), type 2 diabetes, treatment for type 2 diabetes, previously diagnosed or treated type 2 diabetes (pediatric only), or serum glucose 11.1 mmol/L (pediatric only). (3) Blood pressure lower of 130/85 mmHg or 95th percentile (age < 13 years), or 130/85 mmHg (age 13 years); or specific hypertensive drug treatment. (4) Plasma triglycerides 1.15 mmol/L (age < 10 years) or 1.70 mmol/L (age 10 years); or lipid lowering treatment. (5) Plasma high-density lipoprotein cholesterol 1.0 mmol/L (adult male, pediatric) or 1.3 mmol/L (adult female); or lipid lowering treatment.
  Synonym: Exact: MAFLD
      MASLD
      NAFLD
      metabolic dysfunction-associated fatty liver disease
      metabolic dysfunction-related steatotic liver disease
      metabolic-associated fatty liver disease
      non-alcoholic fatty liver disease
      nonalcoholic fatty liver disease
  Parent: Is_a: DOID:9452
  Child: Is: DOID:0080546
      DOID:0080547
  DB_info: Database: OMIM disease 613282
          613387
  Attribute_of: Gene_by_orthology (25)