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WormBase Tree Display for Variation: WBVar00143373

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Name Class

WBVar00143373NamePublic_namee652
Sequence_detailsMapping_targetF47A4
SeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004192
LaboratoryCB
StatusLive
AffectsGeneWBGene00001081
InteractorWBInteraction000052284
GeneticsMapping_dataIn_2_point624
3153
3156
In_multi_point531
532
533
1195
1196
In_pos_neg_data3154
DescriptionPhenotypeWBPhenotype:0000031Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkslow-growing (XX)Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000032Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
RemarkXX and XO animals are sick.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
WBls:0000056PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
WBPhenotype:0000065Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkvery abnormal small or inviable male (XO)Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000314Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000409Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkvariable, difficult to score (ES2) at all XX stages XX, easy to score (ES3) at all X0 stagesPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES2_Difficult_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000583Paper_evidenceWBPaper00001011
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkXX and XO animals are strong dumpy.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
WBls:0000056PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
WBPhenotype:0001582Paper_evidenceWBPaper00001011
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkXX animals have slightly enhanced lin-14 mutant seam cells (41% n=20) compared to lin-14 animals alone (30% n=40). XO males have 79% (n=20) mutant seam cell nuclei, which is significantly higher than XO lin-14 animals (50% n=20) and more similar to lin-14/Df XX animals (84% n=20).Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
reduced X chromosome expressionPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
WBls:0000056PATO:0000460Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Genotypelin-14(n179) or him-5/+; lin-14(n179)/0Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000064Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
RemarkNo strong bias in viability between XX (83%, n=569) and XO (78%, n=377) animals were observed.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
Phenotype_assayTreatmentXX viability was determined directly by counts of eggs from homozygous dpy-22 hermaphrodites and following development through adulthood. XO viability was determined by counts of progeny from dpy-22 hermaphrodites mated to WT males.Paper_evidenceWBPaper00001011
Curator_confirmedWBPerson712
ReferenceWBPaper00001011
WBPaper00016237
WBPaper00016243
WBPaper00016415
RemarkThis allele causes a frameshift after the G residue at amino acid position 2333.Paper_evidenceWBPaper00025050
MethodAllele