WormBase Tree Display for Variation: WBVar00143087

WBVar00143087 Name: Public_name: e286
    Other_name: F30H5.1.1:c.2464C>T
      CE01925:p.Leu822Phe
    HGVSg: CHROMOSOME_III:g.500483C>T
  Sequence_details: SMap: S_parent: Sequence: F30H5
    Flanking_sequences: ccattttcagcccggaaccgatcgtctgaaa tctgggttctctactcggcagaagttgaaga
    Mapping_target: F30H5
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00003295
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004142
      WBStrain00006360
      WBStrain00026328
      WBStrain00033497
      WBStrain00033521
      WBStrain00034257
      WBStrain00035413
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00006781
    Transcript: F30H5.1.1 (12)
    Interactor: WBInteraction000534891
      WBInteraction000534893
      WBInteraction000534895
      WBInteraction000534897
      WBInteraction000560388
  Isolation: Mutagen: hydroxylamine
  Genetics: Interpolated_map_position: III -26.82
    Mapping_data: In_2_point: 50
        623
        6052
      In_multi_point: 67
        856
        857
        1580
        1628
        1630
        1632
        2337
        2338
        3291
  Description: Phenotype (16)
    Phenotype_not_observed: WBPhenotype:0000518 Paper_evidence: WBPaper00046852
        Curator_confirmed: WBPerson2987
        Remark: "A single amino acid substitute in the UCS domain of C-elegans UNC-45, E781K, or L822F (the m94 and e286 alleles, respectively), results in temperature-sensitive motility defects (Figure 1B) and myosin disorganization phenotypes (Figure 1C) when animals are grown at restrictive conditions (>22 degrees Celsius). However, animals show no phenotypes during development and early adulthood when grown at the permissive temperature (15 degrees Celsius C)." Paper_evidence: WBPaper00046852
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Temperature: 15 Paper_evidence: WBPaper00046852
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000644 Paper_evidence: WBPaper00046852
        Curator_confirmed: WBPerson5063
        Remark: At 15C animals are WT on control RNAi but are fully paralyzed on daf-21, C01G10.8, sti-1 or ZC395.10 RNAi. WT animals do not show paralysis when treated with these RNAi. Paper_evidence: WBPaper00046852
            Curator_confirmed: WBPerson5063
        Phenotype_assay: Temperature: 15 Paper_evidence: WBPaper00046852
              Curator_confirmed: WBPerson5063
      WBPhenotype:0001645 Paper_evidence: WBPaper00040284
        Curator_confirmed: WBPerson2987
        Remark: Table S2 Paper_evidence: WBPaper00040284
            Curator_confirmed: WBPerson2987
  Reference (12)
  Method: Substitution_allele