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WormBase Tree Display for Interaction: WBInteraction000549474

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Name Class

WBInteraction000549474Interaction_typeRegulatoryChange_of_localization
InteractorInteractor_overlapping_geneWBGene00000912Interactor_typeTrans_regulated
TransgeneWBTransgene00005218
ConstructWBCnstr00005195
WBGene00000803Interactor_typeTrans_regulator
Interaction_summary"Although in the absence of UV DAF-16::GFP was completely cytoplasmic, we observed a transient nuclear localization following UV treatment during larval stages (L1 larvae Fig. 1c; L3 larvae Supplementary Fig. 1G). DAF-16 showed nearly complete and prolonged nuclear localization in completely NER- and TC-NER-deficient mutants following UV damage, whereas GG-NER-defective worms behaved similarly to WT animals (Fig. 1c and Supplementary Fig. 1G), suggesting that transcription-blocking lesions lead to activation of DAF-16."
Detection_methodConstruct
Reporter_gene[DAF-16::GFP]
Transgene
Regulation_levelPost_translational
Regulation_resultNegative_regulateLife_stageWBls:0000108
Subcellular_localizationnucleus
PaperWBPaper00047070
RemarkFig. S1g