WormBase Tree Display for Interaction: WBInteraction000549474
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WBInteraction000549474 | Interaction_type | Regulatory | Change_of_localization | ||
---|---|---|---|---|---|
Interactor | Interactor_overlapping_gene | WBGene00000912 | Interactor_type | Trans_regulated | |
Transgene | WBTransgene00005218 | ||||
Construct | WBCnstr00005195 | ||||
WBGene00000803 | Interactor_type | Trans_regulator | |||
Interaction_summary | "Although in the absence of UV DAF-16::GFP was completely cytoplasmic, we observed a transient nuclear localization following UV treatment during larval stages (L1 larvae Fig. 1c; L3 larvae Supplementary Fig. 1G). DAF-16 showed nearly complete and prolonged nuclear localization in completely NER- and TC-NER-deficient mutants following UV damage, whereas GG-NER-defective worms behaved similarly to WT animals (Fig. 1c and Supplementary Fig. 1G), suggesting that transcription-blocking lesions lead to activation of DAF-16." | ||||
Detection_method | Construct | ||||
Reporter_gene | [DAF-16::GFP] | ||||
Transgene | |||||
Regulation_level | Post_translational | ||||
Regulation_result | Negative_regulate | Life_stage | WBls:0000108 | ||
Subcellular_localization | nucleus | ||||
Paper | WBPaper00047070 | ||||
Remark | Fig. S1g |