WormBase Tree Display for Interaction: WBInteraction000549469
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| WBInteraction000549469 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00000912 | Interactor_type | Trans_regulated | |
| Transgene | WBTransgene00005218 | ||||
| Construct | WBCnstr00005195 | ||||
| Other_interactor | UV | Interactor_type | Trans_regulator | ||
| Interaction_summary | "Although in the absence of UV DAF-16::GFP was completely cytoplasmic, we observed a transient nuclear localization following UV treatment during larval stages (L1 larvae Fig. 1c; L3 larvae Supplementary Fig. 1G). DAF-16 showed nearly complete and prolonged nuclear localization in completely NER- and TC-NER-deficient mutants following UV damage, whereas GG-NER-defective worms behaved similarly to WT animals (Fig. 1c and Supplementary Fig. 1G), suggesting that transcription-blocking lesions lead to activation of DAF-16." | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [DAF-16::GFP] | ||||
| Transgene | |||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Life_stage | WBls:0000108 | ||
| Subcellular_localization | nucleus | ||||
| Paper | WBPaper00047070 | ||||
| Remark | Fig. S1g |
