WormBase Tree Display for Gene: WBGene00022500
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| WBGene00022500 | Evidence | Paper_evidence | WBPaper00013452 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | ZC8 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | lfi-1 | Person_evidence | WBPerson732 | |||||
| Sequence_name | ZC8.4 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | CELE_ZC8.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lfi-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 04 Jun 2004 10:29:58 | WBPerson1971 | Name_change | CGC_name | lfi-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lfi | ||||||||
| Allele (252) | |||||||||
| Strain | WBStrain00032313 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00023076 | ||||||||
| 00023077 | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00018051 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lfi-1 encodes, by alternative splicing, at least four isoforms of alarge coiled-coil protein paralogous to F35D11.11, and possiblyorthologous to rootletin (the structural protein comprising ciliaryrootlets); LFI-1 is also homologous to the Parascaris univalens MitoticAntigen, PUMA1; LFI-1 was initially identified in yeast two-hybrid screens for proteins that interact with the coiled-coil protein LIN-5, which is essential for proper spindle positioning and chromosome segregation; antibody staining reveals that, in embryos, LFI-1 is expressed in metaphase cells in a diffuse area surrounding the kinetochore microtubules and overlapping with LIN-5 localization; in interphase cells, LFI-1 localizes to the nucleus and remains in the nuclear region even after nuclear envelope breakdown; as loss of lfi-1 activity, or the combined activities of lfi-1 and a related gene, F35D11.11, by RNAi results in no obvious defects, the precise role of LFI-1 in development is not yet known. | Paper_evidence | WBPaper00024244 | |||||
| WBPaper00029004 | |||||||||
| WBPaper00029016 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Feb 2007 00:00:00 | ||||||||
| Automated_description | Located in kinetochore microtubule and nucleus. Is an ortholog of human CROCC (ciliary rootlet coiled-coil, rootletin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | EFO:0009151 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1859) | ||||
| Molecular_info | Corresponding_CDS | ZC8.4a | |||||||
| ZC8.4d | |||||||||
| ZC8.4e | |||||||||
| ZC8.4f | |||||||||
| ZC8.4g | |||||||||
| ZC8.4h | |||||||||
| Corresponding_CDS_history | ZC8.4b:wp145 | ||||||||
| ZC8.4b:wp272 | |||||||||
| ZC8.4c:wp145 | |||||||||
| ZC8.4d:wp272 | |||||||||
| ZC8.4e:wp272 | |||||||||
| Corresponding_transcript | ZC8.4a.1 | ||||||||
| ZC8.4a.2 | |||||||||
| ZC8.4a.3 | |||||||||
| ZC8.4a.4 | |||||||||
| ZC8.4d.1 | |||||||||
| ZC8.4e.1 | |||||||||
| ZC8.4f.1 | |||||||||
| ZC8.4g.1 | |||||||||
| ZC8.4h.1 | |||||||||
| Other_sequence (219) | |||||||||
| Associated_feature | WBsf648060 | ||||||||
| WBsf648061 | |||||||||
| WBsf978486 | |||||||||
| WBsf1005147 | |||||||||
| WBsf1005148 | |||||||||
| WBsf1022896 | |||||||||
| WBsf235646 | |||||||||
| WBsf235647 | |||||||||
| WBsf235648 | |||||||||
| Transcription_factor | WBTranscriptionFactor000405 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00021759 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00002294 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062893 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038104 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059021 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017162 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070889 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034411 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062898 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070888 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2936 | ||||||||
| Expr1013576 | |||||||||
| Expr1039943 | |||||||||
| Expr1162452 | |||||||||
| Expr2013090 | |||||||||
| Expr2031322 | |||||||||
| Drives_construct | WBCnstr00024200 | ||||||||
| Construct_product | WBCnstr00024200 | ||||||||
| WBCnstr00038856 | |||||||||
| Antibody | WBAntibody00000895 | ||||||||
| WBAntibody00001192 | |||||||||
| Microarray_results (48) | |||||||||
| Expression_cluster (263) | |||||||||
| Interaction (51) | |||||||||
| Map_info | Map | X | Position | -6.19862 | Error | 0.000328 | |||
| Positive | Positive_clone | ZC8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00010599 | ||||||||
| WBPaper00018632 | |||||||||
| WBPaper00023417 | |||||||||
| WBPaper00024244 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
