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WormBase Tree Display for Gene: WBGene00020307

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Name Class

WBGene00020307SMapS_parentSequenceT07D3
IdentityVersion1
NameSequence_nameT07D3.4
Molecular_nameT07D3.4a
T07D3.4a.1
CE13361
T07D3.4b
CE51164
T07D3.4b.1
Other_nameCELE_T07D3.4Accession_evidenceNDBBX284602
Public_nameT07D3.4
DB_infoDatabaseAceViewgene2B179
WormQTLgeneWBGene00020307
WormFluxgeneWBGene00020307
OMIMdisease253800
611588
611615
613152
gene607440
NDBlocus_tagCELE_T07D3.4
PanthergeneCAEEL|WormBase=WBGene00020307|UniProtKB=O16723
familyPTHR15407
NCBIgene173469
RefSeqproteinNM_061439.7
NM_001318301.3
TrEMBLUniProtAccO16723
A0A0S4XRC0
UniProt_GCRPUniProtAccO16723
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:02WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
StatusLive
Gene_infoBiotypeSO:0001217
Allele (167)
StrainWBStrain00031550
RNASeq_FPKM (74)
GO_annotation00001837
Ortholog (57)
ParalogWBGene00011554Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00017877Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
WBGene00020924Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00021249Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00020309Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
WBGene00020308Caenorhabditis elegansFrom_analysisTreeFam
WBGene00020927Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00045475Caenorhabditis elegansFrom_analysisPanther
Structured_descriptionConcise_descriptionT07D3.4 is orthologous to the human gene, Fukutin (FKTN, also called FCMD).Paper_evidenceWBPaper00038491
Curator_confirmedWBPerson324
WBPerson1823
WBPerson567
Date_last_updated07 Jun 2012 00:00:00
Automated_descriptionPredicted to be involved in protein glycosylation. Human ortholog(s) of this gene implicated in Fukuyama congenital muscular dystrophy; Walker-Warburg syndrome; autosomal recessive limb-girdle muscular dystrophy type 2L; autosomal recessive limb-girdle muscular dystrophy type 2M; dilated cardiomyopathy (multiple); and muscular dystrophy-dystroglycanopathy type B4. Is an ortholog of human FKTN (fukutin).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050560Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3622)
DOID:0050559Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3622)
DOID:0110443Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3622)
DOID:9884Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3622)
DOID:0112379Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3622)
DOID:0110296Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3622)
DOID:0110444Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3622)
DOID:0110284Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3622)
Disease_relevanceThe human ortholog of elegans TO7D3.4, Fukutin, is required for normal glycosylation of the cell surface laminin receptor, alpha-dystroglycan; mutations in Fukutin cause cardiomyopathy and Fukuyama-type congenital muscular dystrophy (FCMD), an inherited condition that predominantly affects the muscles, brain, and eyes, due to weakness and wasting of skeletal muscles.Homo sapiensAccession_evidenceOMIM611615
253800
613152
611588
607440
Curator_confirmedWBPerson324
Date_last_updated11 Jun 2012 00:00:00
Molecular_infoCorresponding_CDST07D3.4a
T07D3.4b
Corresponding_transcriptT07D3.4a.1
T07D3.4b.1
Other_sequenceOden_isotig15156
Oden_isotig21890
Dviv_isotig31365
Associated_featureWBsf643929
WBsf643930
WBsf986513
WBsf986514
WBsf986515
WBsf1011453
WBsf1011454
WBsf220796
Experimental_infoRNAi_resultWBRNAi00035302Inferred_automaticallyRNAi_primary
WBRNAi00052752Inferred_automaticallyRNAi_primary
WBRNAi00018361Inferred_automaticallyRNAi_primary
WBRNAi00115898Inferred_automaticallyRNAi_primary
Expr_patternExpr1013786
Expr1038847
Expr1156361
Expr2005965
Expr2024181
Drives_constructWBCnstr00025231
Construct_productWBCnstr00025231
Microarray_results (15)
Expression_cluster (148)
InteractionWBInteraction000389723
WBInteraction000446865
Map_infoPositivePositive_cloneT07D3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Interpolated_map_positionII-15.5897
ReferenceWBPaper00038491
WBPaper00055090
WBPaper00062840
MethodGene