WormBase Tree Display for Gene: WBGene00013683

WBGene00013683 SMap: S_parent: Sequence: Y105E8A
  Identity: Version: 3
    Name: CGC_name: zoo-1 Person_evidence: WBPerson240
      Sequence_name: Y105E8A.26
      Molecular_name (12)
      Other_name: tag-301
        Y105E8C.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y105E8A.26 Accession_evidence: NDB BX284601
      Public_name: zoo-1
    DB_info: Database: WormQTL gene WBGene00013683
        WormFlux gene WBGene00013683
        NDB locus_tag CELE_Y105E8A.26
        Panther gene CAEEL|WormBase=WBGene00013683|UniProtKB=Q8I103
          family PTHR13865
        NCBI gene 173316
        RefSeq protein NM_001265448.4
            NM_001377679.2
            NM_001265449.3
            NM_001265447.4
        TREEFAM TREEFAM_ID TF315606
        TrEMBL UniProtAcc H1UBL0
            Q8I103
            H1UBK9
            Q56VX4
        UniProt_GCRP UniProtAcc Q8I103
        OMIM gene 607709
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 22 Apr 2005 11:55:18 WBPerson2970 Name_change: CGC_name: tag-301
        3 18 Jul 2008 14:49:34 WBPerson2970 Name_change: CGC_name: zoo-1
                Other_name: tag-301
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: zoo
    Allele (328)
    Strain: WBStrain00036157
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (43)
    Paralog: WBGene00009678 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: zoo-1 encodes a protein ortholog of the zonula occludens (ZO) subfamily of membrane-associated guanylate kinases (MAGUKs); zoo-1 is involved in the recruitment of actin to cell junctions in a hmr-1/cadherin dependant manner; genetic interaction studies indicate that zoo-1 acts together with hmp-1/alpha-catenin and hmp-2/beta-catenin for the proper organization of actin at epidermal junctions during epthelial morphogenesis; consistant with these roles, zoo-1 expression is enriched at epidermal cell borders; zoo-1 is also expressed in myoblasts and mature muscle cells. Paper_evidence: WBPaper00032115
          Curator_confirmed: WBPerson324
          Date_last_updated: 02 Oct 2008 00:00:00
      Automated_description: Predicted to enable cell adhesion molecule binding activity. Involved in actin filament organization; embryo development; and embryonic morphogenesis. Located in adherens junction and bicellular tight junction. Human ortholog(s) of this gene implicated in biliary tract cancer (multiple); disease of metabolism; and progressive familial intrahepatic cholestasis 4. Is an ortholog of human TJP2 (tight junction protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070224 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11828)
      EFO:MONDO:0100327 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11828)
      DOID:0014667 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11828)
      DOID:4948 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11827)
      DOID:4606 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11827)
  Molecular_info: Corresponding_CDS: Y105E8A.26a
      Y105E8A.26b
      Y105E8A.26c
      Y105E8A.26d
    Corresponding_CDS_history: Y105E8A.26:wp141
      Y105E8A.26a:wp274
      Y105E8A.26b:wp274
      Y105E8A.26e:wp274
    Corresponding_transcript: Y105E8A.26a.1
      Y105E8A.26b.1
      Y105E8A.26c.1
      Y105E8A.26d.1
    Other_sequence (17)
    Associated_feature (25)
  Experimental_info: RNAi_result: WBRNAi00077670 Inferred_automatically: RNAi_primary
      WBRNAi00077672 Inferred_automatically: RNAi_primary
      WBRNAi00077671 Inferred_automatically: RNAi_primary
      WBRNAi00077669 Inferred_automatically: RNAi_primary
      WBRNAi00077673 Inferred_automatically: RNAi_primary
      WBRNAi00077667 Inferred_automatically: RNAi_primary
      WBRNAi00077668 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8262
      Expr1017535
      Expr1036113
      Expr1158763
      Expr2018184
      Expr2036321
    Drives_construct: WBCnstr00000673
    Antibody: WBAntibody00001451
    Microarray_results (27)
    Expression_cluster (108)
    Interaction (58)
  Map_info: Map: I Position: 25.7875 Error: 0.008141
    Positive: Positive_clone: Y105E8A Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5190
    Pseudo_map_position
  Reference: WBPaper00032115
    WBPaper00038491
    WBPaper00055090
    WBPaper00060562
    WBPaper00065034
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene