WormBase Tree Display for Gene: WBGene00012342
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| WBGene00012342 | SMap | S_parent | Sequence | W08D2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mtr-4 | Person_evidence | WBPerson699 | |||||
| WBPerson6229 | |||||||||
| Sequence_name | W08D2.7 | ||||||||
| Molecular_name | W08D2.7 | ||||||||
| W08D2.7.1 | |||||||||
| CE06562 | |||||||||
| Other_name | CELE_W08D2.7 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | mtr-4 | ||||||||
| DB_info | Database | AceView | gene | 4K593 | |||||
| WormQTL | gene | WBGene00012342 | |||||||
| WormFlux | gene | WBGene00012342 | |||||||
| NDB | locus_tag | CELE_W08D2.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00012342|UniProtKB=Q23223 | |||||||
| family | PTHR12131 | ||||||||
| NCBI | gene | 177824 | |||||||
| RefSeq | protein | NM_069356.6 | |||||||
| SwissProt | UniProtAcc | Q23223 | |||||||
| TREEFAM | TREEFAM_ID | TF300597 | |||||||
| UniProt_GCRP | UniProtAcc | Q23223 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 04 Jun 2007 15:54:19 | WBPerson2970 | Name_change | CGC_name | mtr-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mtr | ||||||||
| Allele (58) | |||||||||
| Possibly_affected_by | WBVar02153240 | ||||||||
| WBVar02153242 | |||||||||
| Strain | WBStrain00002572 | ||||||||
| WBStrain00032681 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00008502 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00012896 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00013189 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016194 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020964 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021905 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mtr-4 encodes the C. elegans homolog of Saccharomyces cerevisiae Mtr4p, an RNA helicase that functions as part of the TRAMP complex that regulates polyadenylation of mRNAs destined for decay or exosomal trimming; loss of mtr-4 activity results in a variety of defects, including defects in germ line development; MTR-4 can be phosphorylated by murine ERK2 in vitro, suggesting that it is a substrate for the RTK-RAS-ERK pathway in vivo. | Paper_evidence | WBPaper00040686 | |||||
| WBPaper00032961 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Jan 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable RNA helicase activity. Predicted to be involved in RNA catabolic process and maturation of 5.8S rRNA. Predicted to be located in nucleus. Expressed in PVDL; PVDR; embryonic cell; and somatic cell. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Is an ortholog of human MTREX (Mtr4 exosome RNA helicase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:332 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18734) | ||||
| Molecular_info | Corresponding_CDS | W08D2.7 | |||||||
| Corresponding_transcript | W08D2.7.1 | ||||||||
| Other_sequence (60) | |||||||||
| Associated_feature | WBsf646257 | ||||||||
| WBsf228881 | |||||||||
| Experimental_info | RNAi_result (30) | ||||||||
| Expr_pattern | Chronogram744 | ||||||||
| Expr6854 | |||||||||
| Expr12216 | |||||||||
| Expr12227 | |||||||||
| Expr15665 | |||||||||
| Expr1011473 | |||||||||
| Expr1035462 | |||||||||
| Expr1158512 | |||||||||
| Expr2013816 | |||||||||
| Expr2032056 | |||||||||
| Drives_construct | WBCnstr00003134 | ||||||||
| WBCnstr00020415 | |||||||||
| WBCnstr00029987 | |||||||||
| Construct_product | WBCnstr00020470 | ||||||||
| WBCnstr00029987 | |||||||||
| WBCnstr00042026 | |||||||||
| WBCnstr00042029 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (126) | |||||||||
| Interaction (193) | |||||||||
| Map_info | Map | IV | Position | 4.42878 | Error | 0.000727 | |||
| Positive | Positive_clone | W08D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00032961 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00046432 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060530 | |||||||||
| WBPaper00064201 | |||||||||
| WBPaper00065012 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
