WormBase Tree Display for Gene: WBGene00011737
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| WBGene00011737 | SMap | S_parent | Sequence | T12G3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sqst-1 | Paper_evidence | WBPaper00042170 | |||||
| Person_evidence | WBPerson716 | ||||||||
| Sequence_name | T12G3.1 | ||||||||
| Molecular_name | T12G3.1a | ||||||||
| T12G3.1a.1 | |||||||||
| CE37554 | |||||||||
| T12G3.1b | |||||||||
| CE45860 | |||||||||
| T12G3.1b.1 | |||||||||
| Other_name | CELE_T12G3.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | sqst-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 05 Apr 2013 16:46:51 | WBPerson2970 | Name_change | CGC_name | sqst-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sqst | ||||||||
| Allele (53) | |||||||||
| Strain | WBStrain00001490 | ||||||||
| WBStrain00037114 | |||||||||
| WBStrain00037157 | |||||||||
| Component_of_genotype | WBGenotype00000083 | ||||||||
| WBGenotype00000084 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (32) | |||||||||
| Paralog | WBGene00012067 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00012516 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00015552 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021495 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sqst-1 encodes a protein with similarity to mammalian sequestosome 1(SQSTM1)/p62, a signal transduction or adaptor protein involved in receptor-mediated signalling pathways; SQST-1 is weakly expressed in embryos and exhibits a diffuse, cytoplasmic localization; SQST-1 is selectively removed by autophagy during embryogenesis. | Paper_evidence | WBPaper00036384 | |||||
| WBPaper00041409 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Oct 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Predicted to be involved in aggrephagy; endosome organization; and mitophagy. Located in cytoplasm. Expressed in several structures, including head; hypodermal cell; muscle cell; tail; and vulva. Human ortholog(s) of this gene implicated in Paget's disease of bone 3; distal myopathy with rimmed vacuoles; and neurodegenerative disease (multiple). Is an ortholog of human SQSTM1 (sequestosome 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:332 | Homo sapiens | Paper_evidence | WBPaper00066343 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 Aug 2021 00:00:00 | ||||||||
| Potential_model | DOID:0081366 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11280) | |||||
| DOID:0110068 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11280) | ||||||
| DOID:0081363 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11280) | ||||||
| DOID:5408 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11280) | ||||||
| DOID:0081364 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11280) | ||||||
| Models_disease_asserted | WBDOannot00001040 | ||||||||
| Molecular_info | Corresponding_CDS | T12G3.1a | |||||||
| T12G3.1b | |||||||||
| Corresponding_CDS_history | T12G3.1:wp132 | ||||||||
| Corresponding_transcript | T12G3.1a.1 | ||||||||
| T12G3.1b.1 | |||||||||
| Other_sequence | CBC08481_1 | ||||||||
| CR00634 | |||||||||
| CRC06360_1 | |||||||||
| CBC06086_1 | |||||||||
| CR03354 | |||||||||
| CBC12582_1 | |||||||||
| CR01694 | |||||||||
| CJC06184_1 | |||||||||
| CRC08734_1 | |||||||||
| CRC12404_1 | |||||||||
| Associated_feature | WBsf646442 | ||||||||
| WBsf660776 | |||||||||
| WBsf660777 | |||||||||
| WBsf660778 | |||||||||
| WBsf981832 | |||||||||
| WBsf998015 | |||||||||
| WBsf1018314 | |||||||||
| WBsf229233 | |||||||||
| WBsf229234 | |||||||||
| WBsf229235 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00113609 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00114688 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033299 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018644 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00053225 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (19) | |||||||||
| Drives_construct | WBCnstr00002349 | ||||||||
| WBCnstr00004318 | |||||||||
| WBCnstr00006906 | |||||||||
| WBCnstr00014783 | |||||||||
| WBCnstr00030429 | |||||||||
| Construct_product | WBCnstr00006906 | ||||||||
| WBCnstr00019922 | |||||||||
| WBCnstr00030429 | |||||||||
| Antibody | WBAntibody00002145 | ||||||||
| WBAntibody00002774 | |||||||||
| WBAntibody00002865 | |||||||||
| WBAntibody00002887 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (335) | |||||||||
| Interaction (77) | |||||||||
| Map_info | Map | IV | Position | 5.51952 | |||||
| Positive | Positive_clone | T12G3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (36) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
