WormBase Tree Display for Gene: WBGene00011095
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| WBGene00011095 | SMap | S_parent | Sequence | R07B7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gana-1 | Paper_evidence | WBPaper00024919 | |||||
| Sequence_name | R07B7.11 | ||||||||
| Molecular_name | R07B7.11 | ||||||||
| R07B7.11.1 | |||||||||
| CE06273 | |||||||||
| Other_name | CELE_R07B7.11 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | gana-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 11 Feb 2005 11:14:24 | WBPerson2970 | Name_change | CGC_name | gana-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gana | ||||||||
| Allele (28) | |||||||||
| Strain | WBStrain00002061 | ||||||||
| WBStrain00033052 | |||||||||
| WBStrain00052080 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | gana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes. the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency. | Paper_evidence | WBPaper00004637 | |||||
| WBPaper00024995 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Jul 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable alpha-galactosidase activity. Involved in glycoside catabolic process. Located in cytoplasm. Expressed in coelomocyte. Used to study Fabry disease. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schindler disease (multiple); and angiokeratoma. Is an ortholog of human GLA (galactosidase alpha) and NAGA (alpha-N-acetylgalactosaminidase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14499 | Homo sapiens | Paper_evidence | WBPaper00024995 | ||||
| Accession_evidence | OMIM | 301500 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 26 Mar 2013 00:00:00 | ||||||||
| Potential_model | DOID:14499 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4296) | |||||
| DOID:0112318 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7631) | ||||||
| DOID:479 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7631) | ||||||
| DOID:0112319 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7631) | ||||||
| DOID:2367 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7631) | ||||||
| Disease_relevance | Elegans gana-1 is orthologous to the human NAGA and GALA genes; the human gene Alpha-N-acetylgalactosaminidase (NAGA, also known as GALB) is a lysosomal glycohydrolase, that cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates; mutations in GALB have been associated with Schindler disease type I and III and Kanzaki disease; mutations in human alpha-galactosidase (GLA), a lysosomal hydrolase are associated with Fabry disease. | Homo sapiens | Paper_evidence | WBPaper00031904 | |||||
| WBPaper00024995 | |||||||||
| Accession_evidence | OMIM | 609242 | |||||||
| 609241 | |||||||||
| 301500 | |||||||||
| 300644 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 May 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000117 | ||||||||
| Molecular_info | Corresponding_CDS | R07B7.11 | |||||||
| Corresponding_transcript | R07B7.11.1 | ||||||||
| Other_sequence (42) | |||||||||
| Associated_feature | WBsf661853 | ||||||||
| WBsf232594 | |||||||||
| WBsf232595 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00034684 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00017514 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051428 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061279 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1180 | ||||||||
| Expr3168 | |||||||||
| Expr6474 | |||||||||
| Expr6475 | |||||||||
| Expr1010714 | |||||||||
| Expr1034872 | |||||||||
| Expr1155117 | |||||||||
| Expr2011940 | |||||||||
| Expr2030177 | |||||||||
| Drives_construct | WBCnstr00002845 | ||||||||
| WBCnstr00004440 | |||||||||
| WBCnstr00011188 | |||||||||
| WBCnstr00030937 | |||||||||
| Construct_product | WBCnstr00011188 | ||||||||
| WBCnstr00016579 | |||||||||
| WBCnstr00016580 | |||||||||
| WBCnstr00030937 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (196) | |||||||||
| Interaction | WBInteraction000123322 | ||||||||
| WBInteraction000396593 | |||||||||
| WBInteraction000416572 | |||||||||
| WBInteraction000504156 | |||||||||
| WBInteraction000551639 | |||||||||
| Map_info | Map | V | Position | 3.62659 | Error | 0.001183 | |||
| Positive | Positive_clone | R07B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00024995 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042257 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064161 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
