WormBase Tree Display for Gene: WBGene00010425
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| WBGene00010425 | SMap | S_parent | Sequence | H37A05 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lpin-1 | Person_evidence | WBPerson8432 | |||||
| Sequence_name | H37A05.1 | ||||||||
| Molecular_name | H37A05.1 | ||||||||
| H37A05.1.1 | |||||||||
| CE46619 | |||||||||
| Other_name | CELE_H37A05.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | lpin-1 | ||||||||
| DB_info | Database | AceView | gene | 5O132 | |||||
| WormQTL | gene | WBGene00010425 | |||||||
| WormFlux | gene | WBGene00010425 | |||||||
| NDB | locus_tag | CELE_H37A05.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00010425|UniProtKB=Q9XXT5 | |||||||
| family | PTHR12181 | ||||||||
| NCBI | gene | 179853 | |||||||
| RefSeq | protein | NM_073979.7 | |||||||
| TREEFAM | TREEFAM_ID | TF314095 | |||||||
| TrEMBL | UniProtAcc | Q9XXT5 | |||||||
| UniProt_GCRP | UniProtAcc | Q9XXT5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 15 Sep 2008 11:24:05 | WBPerson2970 | Name_change | CGC_name | lpin-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lpin | ||||||||
| Allele (56) | |||||||||
| Strain | WBStrain00001552 | ||||||||
| WBStrain00029193 | |||||||||
| WBStrain00029194 | |||||||||
| WBStrain00037085 | |||||||||
| WBStrain00053909 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (49) | |||||||||
| Structured_description | Concise_description | lpin-1 encodes a putative phosphatidic acid phosphatase orthologous tobudding yeast PAH1 and human LPIN1 (OMIM:605518), LPIN2 (OMIM:605519,mutated in Majeed syndrome), and LPIN3 (OMIM:605520); lpin-1 isexpressed in vulval muscle; in mass RNAi assays, lpin-1 is requiredfor the osmotic integrity of eggs and for normal larval growth, bodythickness, locomotion, and fertility; by orthology, LPIN-1 is expectedto be dephosphorylated by SCPL-2. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00006525 | |||||||||
| WBPaper00024497 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00029274 | |||||||||
| WBPaper00029281 | |||||||||
| WBPaper00029282 | |||||||||
| WBPaper00029283 | |||||||||
| WBPaper00029284 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Involved in several processes, including endomembrane system organization; macromolecule localization; and nematode larval development. Located in endoplasmic reticulum; nuclear envelope; and nucleoplasm. Expressed in head neurons and hypodermis. Used to study obesity. Human ortholog(s) of this gene implicated in morbid obesity. Is an ortholog of human LPIN2 (lipin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00033438 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 11 Jun 2018 00:00:00 | ||||||||
| Potential_model | DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13345) | |||||
| Models_disease_asserted | WBDOannot00000542 | ||||||||
| Molecular_info | Corresponding_CDS | H37A05.1 | |||||||
| Corresponding_CDS_history | H37A05.1:wp229 | ||||||||
| Corresponding_transcript | H37A05.1.1 | ||||||||
| Other_sequence (51) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result (65) | ||||||||
| Expr_pattern | Chronogram1159 | ||||||||
| Expr6290 | |||||||||
| Expr8650 | |||||||||
| Expr8695 | |||||||||
| Expr11676 | |||||||||
| Expr1026973 | |||||||||
| Expr1034547 | |||||||||
| Expr1153265 | |||||||||
| Expr2013257 | |||||||||
| Expr2031488 | |||||||||
| Drives_construct | WBCnstr00002394 | ||||||||
| WBCnstr00013464 | |||||||||
| WBCnstr00015871 | |||||||||
| WBCnstr00015872 | |||||||||
| Construct_product | WBCnstr00013464 | ||||||||
| WBCnstr00015871 | |||||||||
| WBCnstr00019172 | |||||||||
| Antibody | WBAntibody00001937 | ||||||||
| WBAntibody00001938 | |||||||||
| WBAntibody00001939 | |||||||||
| WBAntibody00001940 | |||||||||
| WBAntibody00002523 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (15) | |||||||||
| Map_info | Map | V | Position | 5.54896 | Error | 0.007081 | |||
| Positive | Positive_clone | H37A05 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
