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WormBase Tree Display for Gene: WBGene00009813

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Name Class

WBGene00009813SMapS_parentSequenceF47B10
IdentityVersion2
NameCGC_namehaly-1Paper_evidenceWBPaper00038278
Person_evidenceWBPerson341
Sequence_nameF47B10.2
Molecular_nameF47B10.2
F47B10.2.1
CE03352
Other_nameCELE_F47B10.2Accession_evidenceNDBBX284606
Public_namehaly-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:50WBPerson1971EventImportedInitial conversion from CDS class of WS125
212 Apr 2011 11:48:32WBPerson2970Name_changeCGC_namehaly-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhaly
Allele (44)
StrainWBStrain00040582
WBStrain00040583
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (30)
Structured_descriptionConcise_descriptionhaly-1 encodes a histidine ammonia lyase orthologous to the human gene HISTIDASE (HAL; OMIM:235800); HALY-1 is required in C. elegans for conversion of histidine to urocanic acid via reductive deamination; loss-of-function mutations in haly-1 result in protection against zinc and nickel toxicity owing to increased levels of metal-chelating histidine; genetic studies suggest that haly-1 functions in parallel to members of the cation diffusion facilitator family of zinc transporters encodes by cdf-1, cdf-2, and sur-7 to modulate zinc sensitivity; haly-1 mRNA levels do not vary under different dietary zinc conditions.Paper_evidenceWBPaper00031911
WBPaper00038278
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated04 Apr 2011 00:00:00
Automated_descriptionPredicted to enable histidine ammonia-lyase activity. Involved in histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0060168Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4806)
Molecular_infoCorresponding_CDSF47B10.2
Corresponding_transcriptF47B10.2.1
Other_sequence (79)
Associated_featureWBsf654368
WBsf237907
WBsf237908
Experimental_infoRNAi_resultWBRNAi00015146Inferred_automaticallyRNAi_primary
WBRNAi00047595Inferred_automaticallyRNAi_primary
WBRNAi00032403Inferred_automaticallyRNAi_primary
Expr_patternChronogram1244
Expr6096
Expr1025610
Expr1034288
Expr1151431
Expr2012363
Expr2030599
Drives_constructWBCnstr00003174
WBCnstr00020173
WBCnstr00031899
Construct_productWBCnstr00020173
WBCnstr00031899
Microarray_results (22)
Expression_cluster (225)
Interaction (19)
Map_infoMapXPosition2.67922
PositivePositive_cloneF47B10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00031911
WBPaper00038278
WBPaper00038491
WBPaper00039078
WBPaper00045887
WBPaper00055090
WBPaper00063976
WBPaper00064232
WBPaper00065140
WBPaper00065331
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene