WormBase Tree Display for Gene: WBGene00006970
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| WBGene00006970 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F28F9 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | zag-1 | Person_evidence | WBPerson110 | |||||
| Sequence_name | F28F9.1 | ||||||||
| Molecular_name | F28F9.1 | ||||||||
| F28F9.1.1 | |||||||||
| CE34546 | |||||||||
| Other_name | zfh-1 | Person_evidence | WBPerson1103 | ||||||
| CELE_F28F9.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | zag-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 30 Sep 2011 14:38:09 | WBPerson2970 | Name_change | Other_name | zfh-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | zag | ||||||||
| Allele (88) | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00000462 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009553 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018446 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | zag-1 encodes a homeodomain protein of the ZFH class which consists of a homeodomain flanked by two clusters of C2H2-type zinc fingers and is related to transcriptional repressors encoded by Drosophila zfh-1 and the vertebrate ZEB genes; ZAG-1 is required for locomotion, for neuronal differentiation, and for proper axonal branching and fasciculation; from late embryogenesis through adult stages of development, ZAG-1 is expressed dynamically in head and tail neurons and in the intestinal and anal depressor muscles. | Paper_evidence | WBPaper00006104 | |||||
| WBPaper00006106 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Aug 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell differentiation. Located in nucleus. Expressed in body wall musculature; enteric muscle; neurons; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Mowat-Wilson syndrome; and corneal dystrophy (multiple). Is an ortholog of human ZEB1 (zinc finger E-box binding homeobox 1) and ZEB2 (zinc finger E-box binding homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110857 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11642) | ||||
| DOID:11555 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11642) | ||||||
| DOID:10487 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14881) | ||||||
| DOID:0060485 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14881) | ||||||
| Molecular_info | Corresponding_CDS | F28F9.1 | |||||||
| Corresponding_CDS_history | F28F9.1:wp88 | ||||||||
| F28F9.1:wp102 | |||||||||
| Corresponding_transcript | F28F9.1.1 | ||||||||
| Other_sequence (23) | |||||||||
| Associated_feature (26) | |||||||||
| Gene_product_binds (9188) | |||||||||
| Transcription_factor | WBTranscriptionFactor000277 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00031537 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00045855 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014064 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115808 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115917 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (20) | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product | WBCnstr00005180 | ||||||||
| WBCnstr00005181 | |||||||||
| WBCnstr00016870 | |||||||||
| WBCnstr00034063 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (228) | |||||||||
| Interaction (92) | |||||||||
| Product_binds_matrix | WBPmat00005565 | ||||||||
| WBPmat00005566 | |||||||||
| WBPmat00005567 | |||||||||
| Map_info | Map | IV | Position | -2.06697 | Error | 0.013802 | |||
| Positive | Positive_clone | F28F9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (30) | |||||||||
| Remark | Sequence connection from [Clark SG] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
