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WormBase Tree Display for Gene: WBGene00006788

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Name Class

WBGene00006788SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_nameunc-53Person_evidenceWBPerson261
Sequence_nameF45E10.1
Molecular_name (24)
Other_nameCELE_F45E10.1Accession_evidenceNDBBX284602
Public_nameunc-53
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143183
Allele (424)
Legacy_informatione404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569).
See also e2432, e2499, n152, n166, n569
[C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG]
StrainWBStrain00026706
WBStrain00026870
WBStrain00032757
WBStrain00034470
WBStrain00034483
WBStrain00037045
WBStrain00004162
WBStrain00004572
WBStrain00005655
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (46)
Structured_descriptionConcise_descriptionunc-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells, axons, and excretory cell canals; unc-53 mutations affect egg laying, backward locomotion, body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with a AAA-ATPase domain; the UNC-53 N-terminus physically interacts with ABI-1, suggesting that UNC-53 may function as a scaffold to link the ARP2/3 complex to ABI-1; UNC-53 also interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth.Paper_evidence (11)
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated13 Nov 2012 00:00:00
Automated_descriptionPredicted to enable actin filament binding activity. Involved in several processes, including backward locomotion; positive regulation of locomotion; and reproductive behavior. Located in cytoplasm. Expressed in several structures, including excretory cell; hermaphrodite distal tip cell; neurons; non-striated muscle; and socket cell. Is an ortholog of human NAV1 (neuron navigator 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:2559Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:15998)
Molecular_infoCorresponding_CDSF45E10.1a
F45E10.1b
F45E10.1c
F45E10.1d
F45E10.1e
F45E10.1f
F45E10.1g
F45E10.1h
Corresponding_CDS_historyF45E10.1:wp82
Corresponding_transcriptF45E10.1a.1
F45E10.1b.1
F45E10.1c.1
F45E10.1d.1
F45E10.1e.1
F45E10.1f.1
F45E10.1g.1
F45E10.1h.1
Other_sequence (27)
Associated_feature (66)
Experimental_infoRNAi_result (14)
Expr_pattern (12)
Drives_construct (25)
Construct_productWBCnstr00009444
WBCnstr00010519
WBCnstr00010520
WBCnstr00010521
WBCnstr00034150
AntibodyWBAntibody00001615
WBAntibody00001625
Microarray_results (40)
Expression_cluster (219)
Interaction (103)
Anatomy_functionWBbtf0113
WBbtf0114
WBbtf0118
WBbtf0119
Map_infoMapIIPosition3.16568Error0.005694
Well_ordered
PositivePositive_cloneF45E10Inferred_automaticallyFrom sequence, transcript, pseudogene data
T28D2
Mapping_data2_point43
Multi_point (11)
Pos_neg_data2145
2146
2159
2163
4533
4534
4535
4536
4539
10562
Reference (99)
MethodGene