WormBase Tree Display for Gene: WBGene00006649
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| WBGene00006649 | Evidence | Person_evidence | WBPerson463 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F08F1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | tth-1 | Person_evidence | WBPerson463 | |||||
| Sequence_name | F08F1.8 | ||||||||
| Molecular_name | F08F1.8 | ||||||||
| F08F1.8.1 | |||||||||
| CE27929 | |||||||||
| F08F1.8.2 | |||||||||
| Other_name | CELE_F08F1.8 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | tth-1 | ||||||||
| DB_info | Database | AceView | gene | XJ42 | |||||
| WormQTL | gene | WBGene00006649 | |||||||
| WormFlux | gene | WBGene00006649 | |||||||
| NDB | locus_tag | CELE_F08F1.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006649|UniProtKB=O17389 | |||||||
| family | PTHR20940 | ||||||||
| NCBI | gene | 181097 | |||||||
| RefSeq | protein | NM_077029.5 | |||||||
| SwissProt | UniProtAcc | O17389 | |||||||
| TREEFAM | TREEFAM_ID | TF313856 | |||||||
| UniProt_GCRP | UniProtAcc | O17389 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tth | ||||||||
| Allele (26) | |||||||||
| Strain | WBStrain00035517 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOPX100 | ||||||||
| Ortholog (23) | |||||||||
| Structured_description | Concise_description | tth-1 encodes a thymosin beta ortholog that contains four functionally distinct thymosin beta repeats; in vitro, TTH-1 binds multiple actin monomers as well as filamentous actin suggesting that, as its homology predicts, TTH-1 plays a direct role in regulating actin polymerization and cytoskeletal organization in C. elegans; consistent with this, loss of tth-1 activity via a deletion mutation that removes upstream sequences results in animals with a dumpy morphology that are sterile as a result of maternal effect lethality associated with deformed oocytes containing abnormally distributed actin; tth-1 mRNA is present throughout development, while TTH-1 protein is detected in the adult gonad in the inside edges of the membranous structures surrounding germline nuclei, the cytoplasm and cortex of oocytes, early embryos at points of cell contact, the developing nerve ring, and then throughout the larval and adult body, with specific enrichment in the intestine and spermatheca. | Paper_evidence | WBPaper00023907 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 Nov 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin monomer binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cytosol. Expressed in distal tip cell; nerve ring; oocyte; spermatheca; and terminal bulb. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F08F1.8 | |||||||
| Corresponding_transcript | F08F1.8.1 | ||||||||
| F08F1.8.2 | |||||||||
| Other_sequence | CJC05583_1 | ||||||||
| CRC01301_1 | |||||||||
| CBC14720_1 | |||||||||
| CR06649 | |||||||||
| CR02116 | |||||||||
| Associated_feature | WBsf670840 | ||||||||
| WBsf1006146 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00044013 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00012902 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033485 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr5681 | ||||||||
| Expr12264 | |||||||||
| Expr12265 | |||||||||
| Expr1016059 | |||||||||
| Expr1032763 | |||||||||
| Expr1147980 | |||||||||
| Expr2017564 | |||||||||
| Expr2035703 | |||||||||
| Drives_construct | WBCnstr00034239 | ||||||||
| Construct_product | WBCnstr00034239 | ||||||||
| Antibody | WBAntibody00001843 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (260) | |||||||||
| Interaction | WBInteraction000038624 | ||||||||
| WBInteraction000351902 | |||||||||
| WBInteraction000354409 | |||||||||
| WBInteraction000565556 | |||||||||
| WBInteraction000578690 | |||||||||
| WBInteraction000580458 | |||||||||
| WBInteraction000583627 | |||||||||
| WBInteraction000584010 | |||||||||
| Map_info | Map | X | Position | -0.047642 | Error | 0.01533 | |||
| Positive | Positive_clone | F08F1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4919 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00023907 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
