WormBase Tree Display for Gene: WBGene00006367
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| WBGene00006367 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sym-2 | Person_evidence | WBPerson252 | |||||
| Sequence_name | ZK1067.6 | ||||||||
| Molecular_name | ZK1067.6a | ||||||||
| ZK1067.6a.1 | |||||||||
| CE35148 | |||||||||
| ZK1067.6b | |||||||||
| CE03707 | |||||||||
| ZK1067.6b.1 | |||||||||
| Other_name | CELE_ZK1067.6 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | sym-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 19 Aug 2005 11:42:03 | WBPerson2970 | Event | Acquires_merge | WBGene00014211 | ||||
| Acquires_merge | WBGene00014211 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sym | ||||||||
| Allele (153) | |||||||||
| Legacy_information | [Herman RK] sym-2(mn617) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation | ||||||||
| Strain | WBStrain00034404 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00013703 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00022253 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020936 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sym-2 encodes a predicted RNA binding protein that contains three RNA recognition motifs (RRMs) similar to those of Drosophila Fusilli and mammalian hnRNP F and H; genetic analyses indicate that, during embryonic development, sym-2 functions redundantly with mec-8, which also encodes an RRM-containing protein, to affect the structure of body wall muscles or their attachment to the body cuticle, perhaps by regulating maturation of transcripts essential for muscle development. | Paper_evidence | WBPaper00003663 | |||||
| WBPaper00024639 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 04 May 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable mRNA binding activity. Involved in embryo development; embryonic body morphogenesis; and multicellular organismal movement. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Is an ortholog of human ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 (epithelial splicing regulatory protein 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111639 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:25966) | ||||
| Molecular_info | Corresponding_CDS | ZK1067.6a | |||||||
| ZK1067.6b | |||||||||
| Corresponding_CDS_history | ZK1067.6:wp106 | ||||||||
| Corresponding_transcript | ZK1067.6a.1 | ||||||||
| ZK1067.6b.1 | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00062554 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00095006 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062552 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022509 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038138 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062553 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059094 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1019298 | ||||||||
| Expr1032566 | |||||||||
| Expr1162524 | |||||||||
| Expr2017180 | |||||||||
| Expr2035316 | |||||||||
| Drives_construct | WBCnstr00034387 | ||||||||
| Construct_product | WBCnstr00034387 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (205) | |||||||||
| Interaction (30) | |||||||||
| Map_info | Map | II | Position | 1.09265 | Error | 0.000921 | |||
| Positive | Positive_clone | ZK1067 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 7090 | |||||||
| 7091 | |||||||||
| Reference (18) | |||||||||
| Method | Gene |
