WormBase Tree Display for Gene: WBGene00004036
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| WBGene00004036 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | plc-1 | Person_evidence | WBPerson51 | |||||
| WBPerson1983 | |||||||||
| Sequence_name | F31B12.1 | ||||||||
| Molecular_name (36) | |||||||||
| Other_name | PLC210 | Paper_evidence | WBPaper00003022 | ||||||
| WBPaper00003365 | |||||||||
| WBPaper00003875 | |||||||||
| WBPaper00003432 | |||||||||
| WBPaper00023291 | |||||||||
| frm-9 | Curator_confirmed | WBPerson4025 | |||||||
| CELE_F31B12.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | plc-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | plc-1 | ||||
| Other_name | frm-9 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | plc | ||||||||
| Allele (621) | |||||||||
| Strain | WBStrain00002612 | ||||||||
| WBStrain00030932 | |||||||||
| WBStrain00030933 | |||||||||
| WBStrain00051732 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00001177 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004045 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004037 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004039 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004038 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | plc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras. | Paper_evidence | WBPaper00003022 | |||||
| WBPaper00023291 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Expressed in excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome type 2; and nephrotic syndrome type 3. Is an ortholog of human PLCE1 (phospholipase C epsilon 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||
| DOID:0080379 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||||
| DOID:1184 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||||
| DOID:0080382 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||||
| Molecular_info | Corresponding_CDS (12) | ||||||||
| Corresponding_CDS_history | F31B12.1a:wp40 | ||||||||
| F31B12.1b:wp40 | |||||||||
| F31B12.1b:wp52 | |||||||||
| Corresponding_transcript (12) | |||||||||
| Other_sequence (49) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00000769 | ||||||||
| WBCnstr00003170 | |||||||||
| WBCnstr00006426 | |||||||||
| WBCnstr00018194 | |||||||||
| WBCnstr00035730 | |||||||||
| Construct_product | WBCnstr00006426 | ||||||||
| WBCnstr00035730 | |||||||||
| Microarray_results (85) | |||||||||
| Expression_cluster (182) | |||||||||
| Interaction (14) | |||||||||
| WBProcess | WBbiopr:00000067 | ||||||||
| Map_info | Map | X | Position | 2.53988 | Error | 0.004789 | |||
| Positive | Positive_clone | F31B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (40) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
