WormBase Tree Display for Gene: WBGene00001834
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| WBGene00001834 | Evidence | CGC_data_submission | |||||
|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C53A5 | ||||
| Identity (6) | |||||||
| Gene_info | Biotype | SO:0001217 | |||||
| Gene_class | hda | ||||||
| Allele (34) | |||||||
| Legacy_information | [Mello C] hda for Histone DeAcetylase related. No mutants known. Predicted gene C53A5.3 | ||||||
| [Hodgkin JA] e1795 hermaphrodites have very abnormal swollen proximal gonad with apparent giant oocytes, additional non-gonadal somatic abnormalities, sterile, variable tail malformation Complementation_data: complements egl-41(e2055) | |||||||
| [C.elegansII] e1795 : hermaphrodites have very abnormal swollen proximal gonad with apparent giant oocytes, additional non-gonadal somatic abnormalities, sterile, variable tail malformationNA1. [CB] | |||||||
| Complementation_data | [Hodgkin JA] complements egl-41(e2055) | ||||||
| Strain | WBStrain00036355 | ||||||
| WBStrain00004649 | |||||||
| WBStrain00054713 | |||||||
| WBStrain00055652 | |||||||
| RNASeq_FPKM (74) | |||||||
| GO_annotation (71) | |||||||
| Ortholog (42) | |||||||
| Paralog | WBGene00001835 | Caenorhabditis elegans | From_analysis | Panther | |||
| WormBase-Compara | |||||||
| WBGene00001836 | Caenorhabditis elegans | From_analysis | Panther | ||||
| WormBase-Compara | |||||||
| WBGene00001837 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| WBGene00001838 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| WBGene00007953 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| WBGene00009657 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| WBGene00009663 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| WBGene00018319 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| WBGene00219378 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| Structured_description | Concise_description | The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development. | Paper_evidence | WBPaper00003050 | |||
| WBPaper00005214 | |||||||
| Curator_confirmed | WBPerson567 | ||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and histone deacetylase activity. Contributes to transcription corepressor activity. Involved in several processes, including developmental process involved in reproduction; negative regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within chromatin organization; determination of adult lifespan; and mitochondrial unfolded protein response. Located in cytoplasm and germ cell nucleus. Part of NuRD complex. Expressed in anchor cell; germ line; nervous system; tail; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); and prostate disease (multiple). Is an ortholog of human HDAC1 (histone deacetylase 1) and HDAC2 (histone deacetylase 2). | Paper_evidence | WBPaper00065943 | ||||
| Curator_confirmed | WBPerson324 | ||||||
| WBPerson37462 | |||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||
| Disease_info | Potential_model (16) | ||||||
| Molecular_info | Corresponding_CDS | C53A5.3 | |||||
| Corresponding_transcript | C53A5.3.1 | ||||||
| Other_sequence (130) | |||||||
| Associated_feature | WBsf647540 | ||||||
| WBsf655135 | |||||||
| WBsf977348 | |||||||
| WBsf977349 | |||||||
| WBsf977350 | |||||||
| WBsf1002050 | |||||||
| WBsf232935 | |||||||
| WBsf232936 | |||||||
| WBsf232937 | |||||||
| Transcription_factor | WBTranscriptionFactor001156 | ||||||
| Experimental_info | RNAi_result (74) | ||||||
| Expr_pattern | Expr2918 | ||||||
| Expr5576 | |||||||
| Expr10987 | |||||||
| Expr11136 | |||||||
| Expr12648 | |||||||
| Expr1014987 | |||||||
| Expr1031079 | |||||||
| Expr1147026 | |||||||
| Expr2012384 | |||||||
| Expr2030620 | |||||||
| Drives_construct | WBCnstr00003241 | ||||||
| WBCnstr00006144 | |||||||
| WBCnstr00006145 | |||||||
| WBCnstr00018008 | |||||||
| WBCnstr00036657 | |||||||
| Construct_product | WBCnstr00036657 | ||||||
| Regulate_expr_cluster | WBPaper00025192:hda-1(RNAi)_downregulated | ||||||
| WBPaper00025192:hda-1(RNAi)_upregulated | |||||||
| WBPaper00061479:hda-1(ne4747)_upregulated | |||||||
| WBPaper00061479:hda-1(ne4748)_upregulated | |||||||
| WBPaper00061479:hda-1(ne4752)_upregulated | |||||||
| WBPaper00061479:HDA-1_interacting_protein | |||||||
| Antibody | WBAntibody00000445 | ||||||
| WBAntibody00000860 | |||||||
| WBAntibody00000922 | |||||||
| WBAntibody00002079 | |||||||
| Microarray_results (19) | |||||||
| Expression_cluster (131) | |||||||
| Interaction (1258) | |||||||
| Anatomy_function | WBbtf0416 | ||||||
| Map_info | Map | V | Position | 6.43888 | Error | 0.006431 | |
| Well_ordered | |||||||
| Positive | Positive_clone | C53A5 | Person_evidence | WBPerson419 | |||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 7042 | |||||
| Multi_point | 3379 | ||||||
| 4335 | |||||||
| 4233 | |||||||
| 5533 | |||||||
| Landmark_gene | |||||||
| Reference (105) | |||||||
| Remark | Sequence connection from [Dufourcq P, Shi Y] | ||||||
| old_name gon-10 becomes new_name hda-1 from [Dufourcq P, Shi Y]. | |||||||
| Method | Gene |
