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WormBase Tree Display for Gene: WBGene00001834

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Name Class

WBGene00001834EvidenceCGC_data_submission
SMapS_parentSequenceC53A5
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classhda
Allele (34)
Legacy_information[Mello C] hda for Histone DeAcetylase related. No mutants known. Predicted gene C53A5.3
[Hodgkin JA] e1795 hermaphrodites have very abnormal swollen proximal gonad with apparent giant oocytes, additional non-gonadal somatic abnormalities, sterile, variable tail malformation Complementation_data: complements egl-41(e2055)
[C.elegansII] e1795 : hermaphrodites have very abnormal swollen proximal gonad with apparent giant oocytes, additional non-gonadal somatic abnormalities, sterile, variable tail malformationNA1. [CB]
Complementation_data[Hodgkin JA] complements egl-41(e2055)
StrainWBStrain00036355
WBStrain00004649
WBStrain00054713
WBStrain00055652
RNASeq_FPKM (74)
GO_annotation (71)
Ortholog (42)
ParalogWBGene00001835Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001836Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001837Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001838Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00007953Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00009657Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00009663Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00018319Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00219378Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionThe hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development.Paper_evidenceWBPaper00003050
WBPaper00005214
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables RNA polymerase II-specific DNA-binding transcription factor binding activity and histone deacetylase activity. Contributes to transcription corepressor activity. Involved in several processes, including developmental process involved in reproduction; negative regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within chromatin organization; determination of adult lifespan; and mitochondrial unfolded protein response. Located in cytoplasm and germ cell nucleus. Part of NuRD complex. Expressed in anchor cell; germ line; nervous system; tail; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); and prostate disease (multiple). Is an ortholog of human HDAC1 (histone deacetylase 1) and HDAC2 (histone deacetylase 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS292 version of WormBase
Date_last_updated24 Apr 2024 00:00:00
Disease_infoPotential_model (16)
Molecular_infoCorresponding_CDSC53A5.3
Corresponding_transcriptC53A5.3.1
Other_sequence (130)
Associated_featureWBsf647540
WBsf655135
WBsf977348
WBsf977349
WBsf977350
WBsf1002050
WBsf232935
WBsf232936
WBsf232937
Transcription_factorWBTranscriptionFactor001156
Experimental_infoRNAi_result (74)
Expr_patternExpr2918
Expr5576
Expr10987
Expr11136
Expr12648
Expr1014987
Expr1031079
Expr1147026
Expr2012384
Expr2030620
Drives_constructWBCnstr00003241
WBCnstr00006144
WBCnstr00006145
WBCnstr00018008
WBCnstr00036657
Construct_productWBCnstr00036657
Regulate_expr_clusterWBPaper00025192:hda-1(RNAi)_downregulated
WBPaper00025192:hda-1(RNAi)_upregulated
WBPaper00061479:hda-1(ne4747)_upregulated
WBPaper00061479:hda-1(ne4748)_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:HDA-1_interacting_protein
AntibodyWBAntibody00000445
WBAntibody00000860
WBAntibody00000922
WBAntibody00002079
Microarray_results (19)
Expression_cluster (131)
Interaction (1258)
Anatomy_functionWBbtf0416
Map_infoMapVPosition6.43888Error0.006431
Well_ordered
PositivePositive_cloneC53A5Person_evidenceWBPerson419
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point7042
Multi_point3379
4335
4233
5533
Landmark_gene
Reference (105)
RemarkSequence connection from [Dufourcq P, Shi Y]
old_name gon-10 becomes new_name hda-1 from [Dufourcq P, Shi Y].
MethodGene