WormBase Tree Display for Gene: WBGene00001834
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| WBGene00001834 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C53A5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | hda-1 | Person_evidence | WBPerson419 | |||||
| Sequence_name | C53A5.3 | ||||||||
| Molecular_name | C53A5.3 | ||||||||
| C53A5.3.1 | |||||||||
| CE08952 | |||||||||
| Other_name | gon-10 | ||||||||
| hdc-1 | Paper_evidence | WBPaper00050597 | |||||||
| Remark | This is a typo from a 2001 publication that is cited. | ||||||||
| CELE_C53A5.3 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | hda-1 | ||||||||
| DB_info | Database | AceView | gene | 5P7 | |||||
| WormQTL | gene | WBGene00001834 | |||||||
| WormFlux | gene | WBGene00001834 | |||||||
| NDB | locus_tag | CELE_C53A5.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001834|UniProtKB=O17695 | |||||||
| family | PTHR10625 | ||||||||
| NCBI | gene | 179959 | |||||||
| RefSeq | protein | NM_074198.10 | |||||||
| KEGG | KEGG_id | 3.5.1.98 | |||||||
| NemaPath | KEGG_id | 3.5.1.98 | |||||||
| SwissProt | UniProtAcc | O17695 | |||||||
| TREEFAM | TREEFAM_ID | TF106171 | |||||||
| UniProt_GCRP | UniProtAcc | O17695 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hda | ||||||||
| Allele (34) | |||||||||
| Legacy_information | [Mello C] hda for Histone DeAcetylase related. No mutants known. Predicted gene C53A5.3 | ||||||||
| [Hodgkin JA] e1795 hermaphrodites have very abnormal swollen proximal gonad with apparent giant oocytes, additional non-gonadal somatic abnormalities, sterile, variable tail malformation Complementation_data: complements egl-41(e2055) | |||||||||
| [C.elegansII] e1795 : hermaphrodites have very abnormal swollen proximal gonad with apparent giant oocytes, additional non-gonadal somatic abnormalities, sterile, variable tail malformationNA1. [CB] | |||||||||
| Complementation_data | [Hodgkin JA] complements egl-41(e2055) | ||||||||
| Strain | WBStrain00036355 | ||||||||
| WBStrain00004649 | |||||||||
| WBStrain00054713 | |||||||||
| WBStrain00055652 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (71) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00001835 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00001836 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001837 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001838 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007953 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009657 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009663 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018319 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00219378 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development. | Paper_evidence | WBPaper00003050 | |||||
| WBPaper00005214 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and histone deacetylase activity. Contributes to transcription corepressor activity. Involved in several processes, including developmental process involved in reproduction; negative regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within chromatin organization; determination of adult lifespan; and mitochondrial unfolded protein response. Located in cytoplasm and germ cell nucleus. Part of NuRD complex. Expressed in anchor cell; germ line; nervous system; tail; and vulva. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); and prostate disease (multiple). Is an ortholog of human HDAC1 (histone deacetylase 1) and HDAC2 (histone deacetylase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
| Disease_info | Potential_model (16) | ||||||||
| Molecular_info | Corresponding_CDS | C53A5.3 | |||||||
| Corresponding_transcript | C53A5.3.1 | ||||||||
| Other_sequence (130) | |||||||||
| Associated_feature | WBsf647540 | ||||||||
| WBsf655135 | |||||||||
| WBsf977348 | |||||||||
| WBsf977349 | |||||||||
| WBsf977350 | |||||||||
| WBsf1002050 | |||||||||
| WBsf232935 | |||||||||
| WBsf232936 | |||||||||
| WBsf232937 | |||||||||
| Transcription_factor | WBTranscriptionFactor001156 | ||||||||
| Experimental_info (10) | |||||||||
| Map_info | Map | V | Position | 6.43888 | Error | 0.006431 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C53A5 | Person_evidence | WBPerson419 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 7042 | |||||||
| Multi_point | 3379 | ||||||||
| 4335 | |||||||||
| 4233 | |||||||||
| 5533 | |||||||||
| Landmark_gene | |||||||||
| Reference (105) | |||||||||
| Remark | Sequence connection from [Dufourcq P, Shi Y] | ||||||||
| old_name gon-10 becomes new_name hda-1 from [Dufourcq P, Shi Y]. | |||||||||
| Method | Gene |
