WormBase Tree Display for Gene: WBGene00001080
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| WBGene00001080 | Evidence | Paper_evidence | WBPaper00006355 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y59A8B | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | dpy-21 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y59A8B.1 | ||||||||
| Molecular_name | Y59A8B.1a | ||||||||
| Y59A8B.1a.1 | |||||||||
| CE26205 | |||||||||
| Y59A8B.1b | |||||||||
| Other_name | Y59A8B.c | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y59A8B.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | dpy-21 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dpy | ||||||||
| Reference_allele | WBVar00143205 | ||||||||
| Allele (428) | |||||||||
| Legacy_information | e428 : weak dumpy (XX) non-dumpy (XO); lethal to 2A;3X. ES3 (adult) ES1 (larvae). ME3. NA3 (e459 (resembles e428) ct16 (very weak dumpy)). | ||||||||
| See also e428, e459, e1483 | |||||||||
| [C.elegansII] e428 : weak dumpy (XX); non-dumpy (XO); lethal to 2A;3X. ES3 (adult) ES1 (larvae).Some X chromosome transcript levels elevated,in both XX and XO. ME3. OA2: e459 (resembles e428), ct16 (very weak phenotype). [Hodgkin 1983b; Meyer and Casson 1986; TY] | |||||||||
| Strain (20) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOP5552 | ||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | dpy-21 encodes a novel, conserved protein with a proline-rich N terminus; dpy-21 affects RNA levels of X-linked dosage-compensated genes, body length in hermaphrodites, and fertility and male tail development in males; DPY-21 interacts in vivo with DPY-27 and SDC-3, members of the dosage compensation complex, and like members of the dosage compensation complex, is diffusely localized in nuclei of XX embryos containing <40 cells, but then specifically localizes to X chromosomes of XX embryos with >40 cells, remaining on the X throughout development; in XO embryos, DPY-21 is dispersed throughout the nucleus in multiple foci that are not coincident with the X chromosome; in hermaphrodites, localization of DPY-21 to the X chromosome requires activity of SDC-2, SDC-3, DPY-26, DPY-27, and DPY-28; DPY-21 is not, however, required reciprocally for the stability or localization of these other dosage compensation proteins; in addition, unlike SDC-3 and other members of the dosage compensation complex, DPY-21 is not recruited to the autosomal her-1 regulatory region, suggesting that DPY-21 is not part of the gene-specific complex that represses her-1 expression in hermaphrodites. | Paper_evidence | WBPaper00000665 | |||||
| WBPaper00000941 | |||||||||
| WBPaper00001003 | |||||||||
| WBPaper00006355 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 17 Jul 2006 00:00:00 | ||||||||
| Automated_description | Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y59A8B.1a | |||||||
| Corresponding_CDS_history | Y59A8B.1:wp139 | ||||||||
| Corresponding_transcript | Y59A8B.1b | ||||||||
| Y59A8B.1a.1 | |||||||||
| Other_sequence (17) | |||||||||
| Associated_feature | WBsf653522 | ||||||||
| WBsf982072 | |||||||||
| WBsf1002778 | |||||||||
| WBsf1002779 | |||||||||
| WBsf014601 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr2896 | ||||||||
| Expr13514 | |||||||||
| Expr1027959 | |||||||||
| Expr1030687 | |||||||||
| Expr1161165 | |||||||||
| Expr2011064 | |||||||||
| Expr2029301 | |||||||||
| Regulate_expr_cluster | WBPaper00050370:dpy-21(e428)_L3_downregulated | ||||||||
| WBPaper00050370:dpy-21(e428)_L3_upregulated | |||||||||
| WBPaper00050801:DPY-21_dauer_regulome | |||||||||
| Antibody | WBAntibody00000707 | ||||||||
| WBAntibody00000708 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (71) | |||||||||
| WBProcess | WBbiopr:00000056 | ||||||||
| Map_info | Map | V | Position | 13.3323 | Error | 0.006986 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | ozDf1 | |||||||
| Positive_clone | Y59A8B | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | ozDf2 | |||||||
| Mapping_data | 2_point (14) | ||||||||
| Multi_point (24) | |||||||||
| Pos_neg_data | 4305 | ||||||||
| 4291 | |||||||||
| 4292 | |||||||||
| 4293 | |||||||||
| 8970 | |||||||||
| 8983 | |||||||||
| Landmark_gene | |||||||||
| Reference (124) | |||||||||
| Method | Gene |
