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WormBase Tree Display for Gene: WBGene00000912

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Name Class

WBGene00000912SMapS_parentSequenceCHROMOSOME_I
IdentityVersion2
NameCGC_namedaf-16Person_evidenceWBPerson521
Sequence_nameR13H8.1
Molecular_name (33)
Other_namedaf-17
CELE_R13H8.1Accession_evidenceNDBBX284601
Public_namedaf-16
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
223 May 2013 11:00:05WBPerson2970EventAcquires_mergeWBGene00043474
Acquires_mergeWBGene00043474
StatusLive
Gene_info (13)
Disease_infoExperimental_modelDOID:9351Homo sapiensPaper_evidenceWBPaper00064218
Curator_confirmedWBPerson324
Date_last_updated07 Nov 2022 00:00:00
DOID:14330Homo sapiensPaper_evidenceWBPaper00045313
Curator_confirmedWBPerson324
Date_last_updated27 Jan 2015 00:00:00
Potential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3821)
DOID:7148Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3821)
DOID:6000Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3819)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3819,HGNC:3821)
DOID:4051Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3819)
DOID:2870Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3821)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3819)
DOID:3328Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3821)
Disease_relevanceParkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species.Homo sapiensPaper_evidenceWBPaper00045313
WBPaper00025083
WBPaper00031384
Curator_confirmedWBPerson324
Date_last_updated27 Jan 2015 00:00:00
In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior.Homo sapiensCurator_confirmedWBPerson324
Modifies_diseaseDOID:332
Models_disease_in_annotationWBDOannot00000340
Modifies_disease_in_annotationWBDOannot00001226
Models_disease_assertedWBDOannot00001357
Molecular_infoCorresponding_CDS (11)
Corresponding_CDS_historyR13H8.1d:wp144
R13H8.1f:wp214
R13H8.1g:wp274
Corresponding_transcript (11)
Other_sequenceJI164490.1
CR02251
Oden_isotig19153
XI04050
BXC01341_1
FN432341.1
FN432342.1
AYC03061_1
Dviv_isotig13041
SSC02558_1
JI166834.1
FN433208.1
CGC01157_1
JI220601.1
CRC02715_1
AY281749.1
XIC02032_1
HGC04106_1
GU584877.1
AE04145
AS10132
JI173146.1
HG09759
SS03246
Dviv_isotig13043
JI164639.1
EX539529.1
EU635467.1
Oden_isotig28977
HG08847
EU635468.1
JI164591.1
AY281750.1
ASC04342_1
BMC01795
Oden_isotig24428
Associated_feature (54)
Gene_product_binds (13568)
Transcription_factorWBTranscriptionFactor000025
Experimental_info (11)
Map_infoMapIPosition5.08393Error0.026229
Well_ordered
PositiveInside_rearrmgDf50
Positive_cloneF55A3Author_evidenceOgg SC
R13H8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point (2)
Multi_point335
336
2218
3631
3703
3886
4480
4913
Reference (1993)
PictureWBPicture0000013078
WBPicture0000013087
RemarkRelated to forkhead/HNF-3 family of winged helix transcription factors [Ogg S]
R13H8.1 must be sequence since it is also forkhead. sdm 141100
MethodGene