WormBase Tree Display for Gene: WBGene00000516
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| WBGene00000516 | SMap | S_parent | Sequence | T05A6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cki-1 | Person_evidence | WBPerson322 | |||||
| Sequence_name | T05A6.1 | ||||||||
| Molecular_name | T05A6.1 | ||||||||
| T05A6.1.1 | |||||||||
| CE03628 | |||||||||
| Other_name | CELE_T05A6.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | cki-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cki | ||||||||
| Allele (11) | |||||||||
| Strain | WBStrain00035555 | ||||||||
| WBStrain00050664 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (25) | |||||||||
| Paralog | WBGene00000517 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms. | Paper_evidence | WBPaper00003201 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including gonad development; regulation of cell cycle process; and regulation of cell division. Located in nucleus. Expressed in several structures, including excretory duct; hermaphrodite somatic gonadal cell; hypodermal cell; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); lung carcinoma (multiple); and urinary system cancer (multiple). Is an ortholog of human CDKN1B (cyclin dependent kinase inhibitor 1B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (15) | ||||||||
| Molecular_info | Corresponding_CDS | T05A6.1 | |||||||
| Corresponding_transcript | T05A6.1.1 | ||||||||
| Other_sequence | AF179358 | ||||||||
| CJC06215_1 | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result (52) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000933 | ||||||||
| WBCnstr00008831 | |||||||||
| WBCnstr00010882 | |||||||||
| WBCnstr00012156 | |||||||||
| WBCnstr00037482 | |||||||||
| Construct_product | WBCnstr00000595 | ||||||||
| WBCnstr00015480 | |||||||||
| WBCnstr00019394 | |||||||||
| WBCnstr00021185 | |||||||||
| WBCnstr00037482 | |||||||||
| WBCnstr00041722 | |||||||||
| Antibody | WBAntibody00000980 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (249) | |||||||||
| Interaction (109) | |||||||||
| Map_info | Map | II | Position | 0.566619 | Error | 0.001788 | |||
| Positive | Positive_clone | T05A6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4221 | |||||||
| 4222 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (120) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
