WormBase Tree Display for Gene: WBGene00000439
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| WBGene00000439 | SMap | S_parent | Sequence | C13G5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ceh-16 | Person_evidence | WBPerson83 | |||||
| Sequence_name | C13G5.1 | ||||||||
| Molecular_name | C13G5.1 | ||||||||
| C13G5.1.1 | |||||||||
| CE37477 | |||||||||
| C13G5.1.2 | |||||||||
| Other_name | CELE_C13G5.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | ceh-16 | ||||||||
| DB_info | Database | AceView | gene | 3J715 | |||||
| WormQTL | gene | WBGene00000439 | |||||||
| WormFlux | gene | WBGene00000439 | |||||||
| NDB | locus_tag | CELE_C13G5.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000439|UniProtKB=P34326 | |||||||
| family | PTHR24341 | ||||||||
| NCBI | gene | 191618 | |||||||
| RefSeq | protein | NM_001392158.1 | |||||||
| SwissProt | UniProtAcc | P34326 | |||||||
| TREEFAM | TREEFAM_ID | TF106461 | |||||||
| UniProt_GCRP | UniProtAcc | P34326 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ceh | ||||||||
| Allele (66) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related.[Kamb et al. 1989] | ||||||||
| [C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related. [Kamb et al. 1989] | |||||||||
| Strain | WBStrain00035877 | ||||||||
| WBStrain00003898 | |||||||||
| WBStrain00008591 | |||||||||
| WBStrain00049293 | |||||||||
| WBStrain00049304 | |||||||||
| WBStrain00055072 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00000462 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00007417 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Structured_description | Concise_description | ceh-16 encodes a homeodomain protein orthologous to Drosophila and vertebrate Engrailed proteins involved in segment and appendage development; ceh-16 is an essential gene required for proper specification and differentiation of the lateral seam cells during embryonic development; in specifying seam cell fates, CEH-16 appears to act as a transcriptional regulator, repressing expression of the eff-1 gene required for cell fusion and inducing expression of seam cell-specific genes such as elt-5/GATA, nhr-73, and nhr-74; in addition, during post-embryonic development, ceh-16 functions to regulate the expansion division of the epidermal seam cells that occurs during the L2 larval stage; in regulating the expansion division, ceh-16 interacts genetically with apr-1, a member of the Wnt signaling pathway that encodes the C. elegans APC ortholog; a rescuing CEH-16::GFP fusion protein is first expressed in the early embryo in cells of the AB lineage; in later embryonic stages CEH-16::GFP is seen in all lateral seam cell nuclei as well as in some anterior neurons; during post-embryonic development, CEH-16::GFP is expressed in the DA1 and DD1 motor neurons. | Paper_evidence | WBPaper00024903 | |||||
| WBPaper00034732 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 03 Jan 2011 00:00:00 | ||||||||
| Automated_description | Enables sequence-specific DNA binding activity. Involved in several processes, including embryonic body morphogenesis; epidermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ABarpa; AIZ; hyp5; retrovesicular ganglion neurons; and seam cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autistic disorder. Is an ortholog of human EN1 (engrailed homeobox 1) and EN2 (engrailed homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3342) | ||||
| DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3343) | ||||||
| Molecular_info | Corresponding_CDS | C13G5.1 | |||||||
| Corresponding_CDS_history | C13G5.1:wp131 | ||||||||
| Corresponding_transcript | C13G5.1.1 | ||||||||
| C13G5.1.2 | |||||||||
| Other_sequence (18) | |||||||||
| Associated_feature | WBsf645428 | ||||||||
| WBsf659322 | |||||||||
| WBsf659323 | |||||||||
| WBsf717952 | |||||||||
| WBsf978805 | |||||||||
| WBsf993415 | |||||||||
| WBsf225446 | |||||||||
| WBsf225447 | |||||||||
| Gene_product_binds (362) | |||||||||
| Transcription_factor | WBTranscriptionFactor000541 | ||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern (20) | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product | WBCnstr00005599 | ||||||||
| WBCnstr00005670 | |||||||||
| WBCnstr00011405 | |||||||||
| WBCnstr00013434 | |||||||||
| WBCnstr00016073 | |||||||||
| WBCnstr00016562 | |||||||||
| WBCnstr00016869 | |||||||||
| WBCnstr00019258 | |||||||||
| WBCnstr00037538 | |||||||||
| Antibody | WBAntibody00000835 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction (97) | |||||||||
| Anatomy_function | WBbtf0067 | ||||||||
| Map_info | Map | III | Position | -0.216271 | Error | 0.001861 | |||
| Positive | Positive_clone | C13G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| CF#EN2 | |||||||||
| Mapping_data | Multi_point | 5618 | |||||||
| Pseudo_map_position | |||||||||
| Reference (29) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
