WormBase Tree Display for Gene: WBGene00000403
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| WBGene00000403 | SMap | S_parent | Sequence | B0034 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | casy-1 | Person_evidence | WBPerson284 | |||||
| WBPerson481 | |||||||||
| Sequence_name | B0034.3 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | cdh-11 | Person_evidence | WBPerson698 | ||||||
| CELE_B0034.3 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | casy-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 05 Jan 2006 11:22:20 | WBPerson2970 | Name_change | CGC_name | casy-1 | ||||
| Other_name | cdh-11 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | casy | ||||||||
| Allele (160) | |||||||||
| Strain | WBStrain00001795 | ||||||||
| WBStrain00001794 | |||||||||
| WBStrain00022694 | |||||||||
| WBStrain00031601 | |||||||||
| WBStrain00055675 | |||||||||
| WBStrain00055105 | |||||||||
| WBStrain00055673 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (46) | |||||||||
| Structured_description | Concise_description | casy-1 encodes a type I transmembrane protein with two extracellular cadherin domains and an LG/LNS domain that is the sole C. elegans calsyntenin/alcadein ortholog; genetic studies indicate that in C. elegans casy-1 activity is required, in parallel to the insulin-like signaling pathway, for several types of learning, including salt chemotaxis learning, temperature learning, olfactory adaptation, and integration of two sensory stimuli; large-scale RNAi experiments also suggest that casy-1 plays a role in embryonic development; casy-1 expression in adult animals is able to rescue salt chemotaxis learning defects, indicating that CASY-1 function in mature animals is sufficient to effect proper chemotactic behavior; in addition, CASY-1 expression in the ASER neuron, but not other neurons, rescues salt chemotaxis learning defects, indicating the CASY-1 can act solely in this chemosensory neuron for normal salt chemotaxis learning; a casy-1::GFP promoter fusion is expressed throughout the nervous system, including the head amphid sensory neurons, with additional expression seen in the intestine and gonadal sheath cells; a CASY-1::GFP protein fusion localizes to the plasma membrane and intracellular membranes of neuronal cell bodies, with specific N-terminal fusions indicative of CASY-1 ectodomain release into the extracellular space; domain-specific rescue experiments indicate that the secreted, proteolytically processed CASY-1 extracellular domain is sufficient to rescue salt chemotaxis learning defects. | Paper_evidence | WBPaper00004508 | |||||
| WBPaper00025054 | |||||||||
| WBPaper00031647 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 03 Apr 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable several functions, including X11-like protein binding activity; amyloid-beta binding activity; and kinesin binding activity. Involved in several processes, including GABAergic synaptic transmission; olfactory learning; and positive regulation of synaptic vesicle transport. Located in several cellular components, including extracellular region; neuromuscular junction; and neuronal cell body membrane. Expressed in neurons. Is an ortholog of human CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | B0034.3a | |||||||
| B0034.3b | |||||||||
| B0034.3c | |||||||||
| B0034.3d | |||||||||
| Corresponding_transcript | B0034.3a.1 | ||||||||
| B0034.3b.1 | |||||||||
| B0034.3c.1 | |||||||||
| B0034.3d.1 | |||||||||
| Other_sequence (80) | |||||||||
| Associated_feature (29) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00038664 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027950 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009558 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038665 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (17) | |||||||||
| Drives_construct | WBCnstr00002178 | ||||||||
| WBCnstr00004247 | |||||||||
| WBCnstr00006267 | |||||||||
| WBCnstr00006270 | |||||||||
| WBCnstr00013090 | |||||||||
| WBCnstr00013091 | |||||||||
| WBCnstr00013376 | |||||||||
| WBCnstr00023001 | |||||||||
| WBCnstr00023062 | |||||||||
| WBCnstr00037567 | |||||||||
| Construct_product | WBCnstr00006267 | ||||||||
| WBCnstr00013091 | |||||||||
| WBCnstr00018580 | |||||||||
| WBCnstr00018581 | |||||||||
| WBCnstr00018582 | |||||||||
| WBCnstr00018583 | |||||||||
| WBCnstr00019712 | |||||||||
| WBCnstr00037567 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (237) | |||||||||
| Interaction (44) | |||||||||
| Map_info | Map | II | Position | -0.800583 | Error | 0.01344 | |||
| Positive | Positive_clone | B0034 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4194 | |||||||
| 4440 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
