WormBase Tree Display for Analysis: RNASeq_Study.SRP010374
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RNASeq_Study.SRP010374 | DB_info | Database | SRA | Study | SRP010374 |
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Title | Ribosome profiling (Stadler 2011) | ||||
Group (2) | |||||
Description | In the universal genetic code, most amino acids can be encoded by multiple trinucleotide codons, and the choice among available codons can influence position-specific translation elongation rates. By using sequence-based ribosome profiling, we obtained transcriptome-wide profiles of in vivo ribosome occupancy as a function of codon identity in Caenorhabditis elegans and human cells. Particularly striking in these profiles was a universal trend of higher ribosome occupancy for codons translated via G:U wobble base-pairing compared with synonymous codons that pair with the same tRNA family using G:C base-pairing. These data support a model in which ribosomal translocation is slowed at wobble codon positions. | ||||
Species_in_analysis | Caenorhabditis elegans | ||||
Reference | WBPaper00040379 |