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WormBase Tree Display for Analysis: RNASeq_Study.SRP010374

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Name Class

RNASeq_Study.SRP010374DB_infoDatabaseSRAStudySRP010374
TitleRibosome profiling (Stadler 2011)
GroupProjectRNASeq.elegans
SubprojectRNASeq.elegans.WBStrain00000001.WBls:0000024.Hermaphrodite.WBbt:0007833.SRP010374.SRX116361
RNASeq.elegans.WBStrain00000001.WBls:0000024.Hermaphrodite.WBbt:0007833.SRP010374.SRX116363
RNASeq.elegans.WBStrain00000001.WBls:0000024.Hermaphrodite.WBbt:0007833.SRP010374.SRX118116
RNASeq.elegans.WBStrain00000001.WBls:0000024.Hermaphrodite.WBbt:0007833.SRP010374.SRX118117
RNASeq.elegans.WBStrain00000001.WBls:0000024.Hermaphrodite.WBbt:0007833.SRP010374.SRX118118
RNASeq.elegans.WBStrain00000001.WBls:0000027.Hermaphrodite.WBbt:0007833.SRP010374.SRX118119
RNASeq.elegans.WBStrain00000001.WBls:0000027.Hermaphrodite.WBbt:0007833.SRP010374.SRX118120
RNASeq.elegans.WBStrain00000001.WBls:0000035.Hermaphrodite.WBbt:0007833.SRP010374.SRX118124
RNASeq.elegans.WBStrain00000001.WBls:0000035.Hermaphrodite.WBbt:0007833.SRP010374.SRX118125
RNASeq.elegans.WBStrain00000001.WBls:0000035.Hermaphrodite.WBbt:0007833.SRP010374.SRX118128
RNASeq.elegans.WBStrain00000001.WBls:0000035.Hermaphrodite.WBbt:0007833.SRP010374.SRX118139
RNASeq.elegans.WBStrain00000001.WBls:0000035.Hermaphrodite.WBbt:0007833.SRP010374.SRX118143
RNASeq.elegans.WBStrain00000001.WBls:0000035.Hermaphrodite.WBbt:0007833.SRP010374.SRX118144
RNASeq.elegans.WBStrain00000001.WBls:0000038.Hermaphrodite.WBbt:0007833.SRP010374.SRX118126
RNASeq.elegans.WBStrain00000001.WBls:0000038.Hermaphrodite.WBbt:0007833.SRP010374.SRX118127
RNASeq.elegans.WBStrain00000001.WBls:0000038.Hermaphrodite.WBbt:0007833.SRP010374.SRX118140
DescriptionIn the universal genetic code, most amino acids can be encoded by multiple trinucleotide codons, and the choice among available codons can influence position-specific translation elongation rates. By using sequence-based ribosome profiling, we obtained transcriptome-wide profiles of in vivo ribosome occupancy as a function of codon identity in Caenorhabditis elegans and human cells. Particularly striking in these profiles was a universal trend of higher ribosome occupancy for codons translated via G:U wobble base-pairing compared with synonymous codons that pair with the same tRNA family using G:C base-pairing. These data support a model in which ribosomal translocation is slowed at wobble codon positions.
Species_in_analysisCaenorhabditis elegans
ReferenceWBPaper00040379