Welcome to WormBase - need help?

WormBase Tree Display for Analysis: RNASeq_Study.SRP010374

expand all nodes | collapse all nodes | view schema

Name Class

RNASeq_Study.SRP010374DB_infoDatabaseSRAStudySRP010374
TitleRibosome profiling (Stadler 2011)
GroupProjectRNASeq.elegans
Subproject (16)
DescriptionIn the universal genetic code, most amino acids can be encoded by multiple trinucleotide codons, and the choice among available codons can influence position-specific translation elongation rates. By using sequence-based ribosome profiling, we obtained transcriptome-wide profiles of in vivo ribosome occupancy as a function of codon identity in Caenorhabditis elegans and human cells. Particularly striking in these profiles was a universal trend of higher ribosome occupancy for codons translated via G:U wobble base-pairing compared with synonymous codons that pair with the same tRNA family using G:C base-pairing. These data support a model in which ribosomal translocation is slowed at wobble codon positions.
Species_in_analysisCaenorhabditis elegans
ReferenceWBPaper00040379