hlb-1 encodes the C. elegans ortholog of human beta-liprin, a coiled-coil domain-containing protein that interacts with alpha-liprin, a transmembrane protein-tyrosine phosphatase-interacting protein; hlb-1 functions cell non-autonomously in the organization and proper function of neuromuscular junctions and hence, is also required for wild type locomotory behavior; an hlb-1 reporter fusion construct directs expression in pharyngeal and body wall muscles, and in regions adjacent to the dorsal and ventral nerve cords; expression in the pharynx is particularly strong in the posterior bulb.
Involved in several processes, including neuromuscular junction development; positive regulation of locomotion; and regulation of nematode pharyngeal pumping. Predicted to be located in presynaptic active zone. Is an ortholog of human PPFIBP1 (PPFIA binding protein 1) and PPFIBP2 (PPFIA binding protein 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
[140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods.