T28C12.4 encodes a protein with visible similarity to human neuroligin 4 (mutated in autism), but also belongs to a large family of carboxylesterases that happen to include NLG-1; normally, T28C12.4 is expressed in hypodermal cells; transcription of T28C12.4 is immediately induced by exposure to ethanol, and with glr-2 is one of a few genes that may be specifically responsive to ethanol (as opposed to other stresses, which are expected to typically induce heat shock genes); the 5' flank of T28C12.4 contains a single ethanol- and stress-responsive element that is required in a T28C12.4::GFP transgene for transcriptional induction by ethanol.
This description was generated automatically by a script based on data from the WS292 version of WormBase
Date_last_updated
24 Apr 2024 00:00:00
Disease_info
Disease_relevance
Human liver carboxylesterases, CES1, CES2 and CES3 (orthologous to C. elegans T28C12.4), metabolize and detoxify drugs and toxins; CESs metabolize ester, thioester, carbamate and amide compounds to acid, alcohol and amine products; mutations in CES1 are associated with Carboxylesterase 1 deficiency.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.