WormBase Tree Display for Gene: WBGene00020891
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WBGene00020891 | SMap | S_parent | Sequence | T28C12 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cest | ||||||
Allele (128) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00026988 | ||||||
00026989 | |||||||
00026990 | |||||||
Ortholog (36) | |||||||
Paralog (41) | |||||||
Structured_description | Concise_description | T28C12.4 encodes a protein with visible similarity to human neuroligin 4 (mutated in autism), but also belongs to a large family of carboxylesterases that happen to include NLG-1; normally, T28C12.4 is expressed in hypodermal cells; transcription of T28C12.4 is immediately induced by exposure to ethanol, and with glr-2 is one of a few genes that may be specifically responsive to ethanol (as opposed to other stresses, which are expected to typically induce heat shock genes); the 5' flank of T28C12.4 contains a single ethanol- and stress-responsive element that is required in a T28C12.4::GFP transgene for transcriptional induction by ethanol. | Paper_evidence | WBPaper00006465 | |||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 11 Feb 2007 00:00:00 | ||||||
Automated_description | Predicted to enable carboxylic ester hydrolase activity. Expressed in hypodermis and seam cell. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||
Disease_info | Disease_relevance | Human liver carboxylesterases, CES1, CES2 and CES3 (orthologous to C. elegans T28C12.4), metabolize and detoxify drugs and toxins; CESs metabolize ester, thioester, carbamate and amide compounds to acid, alcohol and amine products; mutations in CES1 are associated with Carboxylesterase 1 deficiency. | Homo sapiens | Accession_evidence | OMIM | 114835 | |
605278 | |||||||
605279 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Jun 2012 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T28C12.4a | |||||
T28C12.4b | |||||||
Corresponding_transcript | T28C12.4a.1 | ||||||
T28C12.4a.2 | |||||||
T28C12.4b.1 | |||||||
T28C12.4b.2 | |||||||
Other_sequence | Oden_isotig05096 | ||||||
Oden_isotig05092 | |||||||
HC05356 | |||||||
Oden_isotig05094 | |||||||
FC555071.1 | |||||||
Dviv_isotig05893 | |||||||
JI174111.1 | |||||||
ACC10412_1 | |||||||
CR10204 | |||||||
Oden_isotig05088 | |||||||
Dviv_isotig05892 | |||||||
CRC07029_1 | |||||||
FG980317.1 | |||||||
HBC08379_1 | |||||||
HCC06866_1 | |||||||
Oden_isotig05089 | |||||||
Oden_isotig05095 | |||||||
Oden_isotig05087 | |||||||
Oden_isotig05090 | |||||||
Oden_isotig05098 | |||||||
Oden_isotig05086 | |||||||
FC546476.1 | |||||||
CRC09834_1 | |||||||
BXC00955_1 | |||||||
FC539281.1 | |||||||
BUC01505_1 | |||||||
Oden_isotig05093 | |||||||
FC539183.1 | |||||||
FC555128.1 | |||||||
Hbac_isotig00962 | |||||||
Oden_isotig05097 | |||||||
CBC09510_1 | |||||||
FC554775.1 | |||||||
Oden_isotig23452 | |||||||
BUC00406_1 | |||||||
Acan_isotig08176 | |||||||
CR10203 | |||||||
FG974046.1 | |||||||
Hbac_isotig00963 | |||||||
CR07522 | |||||||
Oden_isotig05091 | |||||||
Associated_feature | WBsf646872 | ||||||
WBsf646873 | |||||||
WBsf661326 | |||||||
WBsf661327 | |||||||
WBsf661328 | |||||||
WBsf661329 | |||||||
WBsf1000225 | |||||||
WBsf1000226 | |||||||
WBsf231867 | |||||||
WBsf231868 | |||||||
Experimental_info | RNAi_result | WBRNAi00054391 | Inferred_automatically | RNAi_primary | |||
WBRNAi00019384 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089171 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00036074 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr2907 | ||||||
Expr1019072 | |||||||
Expr1039101 | |||||||
Expr1157938 | |||||||
Expr2006605 | |||||||
Expr2024821 | |||||||
Drives_construct (2) | |||||||
Construct_product | WBCnstr00024806 | ||||||
Microarray_results (25) | |||||||
Expression_cluster (204) | |||||||
Interaction (33) | |||||||
Map_info | Map | V | Position | -0.18384 | |||
Positive | Positive_clone | T28C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00006465 | ||||||
WBPaper00010030 | |||||||
WBPaper00016665 | |||||||
WBPaper00032322 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |