P granule biogenesis and organization
Germ granule proteins are found among a wide variety of species. In C. elegans, these granules are known as P granules. They are initially seen in the cytoplasm of oocytes and early embryos. In early embryogenesis they are asymmetrically segregated into blastomeres that eventually give rise to the germ line. In adults, P granules are peri-nuclear and cluster with nuclear pore complexes. They are associated with RNA metabolism and appear to play a role in nascent mRNA release from the nucleus.