- YFR035C
Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein
- YCR050C
Saccharomyces cerevisiae Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
- YDR215C
Saccharomyces cerevisiae Putative protein of unknown function; conserved across S. cerevisiae strains; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
- YGL262W
Saccharomyces cerevisiae Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
- YJL118W
Saccharomyces cerevisiae Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
- YBR013C
Saccharomyces cerevisiae Putative protein of unknown function; haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum while mCherry fusion protein localizes to both the endoplasmic reticulum and vacuole
- YDL085C-A
Saccharomyces cerevisiae Homolog of modifier of aggregation-4 (MOAG-4) from worm and small EDRK-rich factor protein (SERF1a) from human; highly conserved enhancer of amyloid formation of Abeta40 and alpha-synuclein both in vitro and in vivo; protein displays very high degree of disorder, segment spanning residues 36E-65K has strong helical propensity
- ENO1
Homo sapiens Isoform alpha-enolase of Alpha-enolase
- YHB1
Saccharomyces cerevisiae Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
- ITGA6
Homo sapiens Isoform Alpha-6X1X2B of Integrin alpha-6