STU2
Saccharomyces cerevisiae Microtubule polymerase of the XMAP215/Dis1 family; required for elongation of mitotic spindle during anaphase, as well as for spindle orientation and metaphase chromosome alignment; stabilizes or destabilizes kinetochore-microtubule attachment depending on kinetochore tension; interacts with spindle pole body component Spc72p; metazoan ch-TOG/XMAP215 family member
SSM4
Saccharomyces cerevisiae Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity