Figure 3. The TIR-1-NSY-1- SEK-1 pathway is required for anoxic death. (A) Drawing of the MAP kinase pathways tested in this study. Survival rate of animals with a mutation in (B) tir- 1
(tm3036), an upstream adaptor protein of NSY-1, (C)
sek-1(
km4), the single MAP2K of the
p38 pathway, and (D)
pmk-1(
km25),
kgb-1(
km21), and
jnk-1(
gk7), MAPKs of the
p38 and JNK pathways. Data represent the mean (6SEM) of the survival fraction from three (B and C) or four (D) independent experiments. P,0.01 and P, 0.05 by one-way analysis of variance and Dunnett's multiple comparison test compared with WT, respectively.