Figure 1. C. elegans contains homologous members of the mitochondrial protein import pathway. A, dendrogram generated by alignment of members of the Tim8 family, Tim9 family, Tim10-12 family, and Tom7 family from C. elegans (Ce), H. sapiens (Hs), M. musculus (Mm), and S. cerevisiae (Sc). Alignment was performed with ClustalW (33). B, the
tin-9.2 gene product is mitochondrial, as shown by the localization of a TIN-9.2::CFP fusion in muscle cells.