- RNA degradation variant
Variations in the regulated breakdown of RNA species via the action of cellular enzymes (RNases) compared to control.
- receptor mediated endocytosis defective
Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes.
- protein stabilization variant
Any variation in the ability of a protein to resist disintegration via chemical or physical modifications compared to control.
- hermaphrodite self sterile
Hermaphrodites fail to produce any viable progeny via self-fertilization. However, such hermaphrodites can successfully reproduce if mated to control males.
- protein toxicity response abnormal
Animals exhibit an abnormal response to toxic proteins, either via exposure in the environment or expressed within the organism, compared to controls.
- cell induction variant
Variations in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling).
- maintenance of gene silencing variant
Animals differ from controls in the expression of genes targeted for silencing (gene inactivation) in subsequent generations via transcriptional or post-transcriptional processes.
- dipeptide repeat protein toxicity abnormal
Animals exhibit an abnormal response to toxic dipeptide repeat proteins, either via exposure in the environment or expressed within the organism, compared to controls.