Animals become paralyzed after a measured amount of time swimming. In C. elegans, more then 80 percent of wild-type animals continue swimming vigorously in liquid even after 30 minutes.
Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background.