- ER stress response variant
Animals exhibit variations in their response to the presence of unfolded proteins in the endoplasmic reticulum (ER) or to other ER-related stressors compared to control.
- ER stress resistant
Animals exhibit a resistance to endoplasmic reticulum (ER) stressors such as an accumulation of unfolded proteins or the presence of chemicals that induce ER stress, such as dithiothreitol (DDT) or tunicamycin, compared to controls. This may mean that animals fare better than controls in terms of survival or some metric of health when exposed to an inducer of ER stress.
- endoplasmic reticulum localization variant
Any variation in the subcellular localization of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that exists in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
- endoplasmic reticulum morphology variant
Any variation in the form, structure or composition of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
- endoplasmic reticulum symmetry variant early emb
Any variation in the normally asymmetric distribution of the endoplasmic reticulum during cell divisions of the early embryo. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
- unfolded protein response variant
Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones.